非典型病原体肺炎诊治进展

The Advances of Diagnosis and Treatment of Pneumonia by Atypical Pathogens

非典型病原体所致的非典型肺炎在社区获得性肺炎中所占比例呈逐年增高趋势。临床表现多样性和病原体检测复杂性一直困扰着临床对非典型肺炎的诊断。近年来,非典型病原体的高耐药性更是严重威胁人类健康。各国的治疗指南认为当不能排除非典型病原体感染时,应经验性选择可覆盖非典型病原体的抗生素。因此,β-内酰胺类+大环内酯类,或单用呼吸喹诺酮类抗菌药物是各国指南均推荐的合理选择。本文对近几年非典型肺炎诊治最新进展做一综述。

The incidence of atypical pneumonia caused by atypical pathogens in community-acquired pneumonia shows an increasing trend year by year. Clinical diagnosis of atypical pneumonia has been plagued by the diversity of clinical manifestation and the complexity of pathogen detection. When we can＇t rule out the infection of atypical pathogen , guidelines recommend to empirically choose antibiotics on covering atypical pathogens. Therefore, the beta lactam ＋ macrolides, or quinolones is the reasonable choice according with national guidelines. In recent years, the high drug- resistance of atypical pathogens seriously threats human health. In this paper, the latest diagnosis and treatment in recent years are reviewed.