骨桥蛋白及其受体CD44v对肿瘤侵袭调控的研究进展

Advances in Research of Osteopontion and Its Receptor CD44v in Tumor Invasion and Metastasis

骨桥蛋白(osteopontion,OPN)是胞外基质中具有多种功能的分泌型糖蛋白,既可作为一种粘附蛋白,参与肿瘤细胞粘附、迁移;又可作为一种细胞因子,促进肿瘤血管形成、逃避免疫监视及抑制细胞凋亡。CD44v糖蛋白是细胞表面粘附分子之一,介导细胞-基质和细胞-细胞间相互作用。近年来大量研究表明OPN及其受体CD44v促进肿瘤侵袭转移,其血清水平与多种肿瘤的预后相关。因此,阐明OPN在肿瘤演进的分子机制及其信号通路有助于寻找一种新颖抗癌疗法。

Osteopontin（OPN） is a multifunctional, extracellular matrix-associated, secretory, glyco-protein. It can be used as an adhesion protein involved in tumor cell adhesion,migration; but also as a cytokine, promoting tumor angiogenesis, evading immune surveillance and inhibiting cellular apoptosis. CD44 v glycoprotein, is one of the cell surface adhesion molecule that mediates cell-matrix and cell-cell interactions. Extensive research has suggested the important role of OPN in regulating signaling pathways that contribute to tumor progression and metastasis, and the serum level is associated with the prognosis of various malignancies. Therefore, clarifying OPN in the molecular mechanisms of tumor progression and its signaling pathway contributes to seeking a novel anti-cancer therapy.