乙型脑炎病毒及其疫苗最新研究进展

The New Development of Japanese Encephalitis Vaccine and Vaccine Research

流行性乙型脑炎(Japanese encephalitis,JE)简称乙脑,是由乙脑病毒感染,流行在亚洲和太平洋地区重要的病毒脑炎,近年乙脑流行地区在不断扩大。目前尚无特效的治疗流行性乙型脑炎的方法,控制蚊虫传播和免疫接种是当前的主要防御手段。随着对乙脑病毒研究的深入,利用基因工程技术研制新型候选疫苗已成为预防乙脑新的发展方向。简要综述了乙型脑炎病毒的基因组结构及其蛋白功能,以及国内外乙型脑炎疫苗的最新研究进展。

Japanese encephalitis （JE）, caused by Japanese encephalitis virus （JEV）infection, is an important viral encephalitis which is prevalent in Asian and Pacific areas. JE endemic areas expanded in recent years. At present there is no specially effective antiviral treatment for JE. Therefore, vaccination and vector control constitute major measures. Sevaral new promising Japanese encephalitis vaccine candidates have been developed. A review on JEV genomic structure and their function, recent advances in the area of Japanese encephalitis vaccine development was given.