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Sca-1＋心脏干细胞移植治疗缺血性心脏病研究进展与面临挑战 被引量：1

The progress of Sca-1 cardiac stem cells in the treatment of patients with ischemic heart disease and the existing problems
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摘要 1 引言传统观点认为，心脏属于有丝分裂后期的器官，无再生和自我修复能力，在负荷量增大或疾病代偿时，通过细胞肥大来适应。因此，心脏受损后心肌组织被瘢痕组织替代从而导致心脏收缩功能障碍，引起心功能不全。
作者 马玉龙 李树仁
机构地区 河北医科大学研究生学院 河北医科大学附属河北省人民医院心脏中心
出处 《中国心血管病研究》 CAS 2015年第11期961-965,共5页 Chinese Journal of Cardiovascular Research
关键词 Sca-1+心脏干细胞 干细胞 心肌梗死 缺血性心脏病 Sca-1＋ cardiac stem cells Stem cells Myocardial infarction Ischemic heart disease
分类号 R541 [医药卫生—心血管疾病]
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参考文献37

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  • 2Kajstura J, Gumsamy N, Ogorek B, et al. Myocyte turnover in the aging human heart. Cire Res,2010, 107:1374-1386.
  • 3郑楠,张宁坤,高连如.成体心肌干细胞的研究进展[J].解放军医学杂志,2013,38(4):334-337. 被引量：6
  • 4王国宏.干细胞治疗缺血性心肌病研究进展[J].中国医刊,2013,48(2):11-14. 被引量：4
  • 5Wang H, Chen H, Feng B, et al. Isolation and characterization of a Sca-1 /CD31- progenitor cell lineage derived from mouse heart tissue. BMC Biotechnology, 2014,14 : 75.
  • 6Nagai T, Matsuura K, Komuro L, et al. Cardiac side population cells and sea-1-positive cells. Methods in Molecular Biology, 2013,1036 : 63-74.
  • 7Bailey B, Fransioli J, Gude NA, et al. Sea-1 knockout impairs myocardial and cardiac progenitor cell function. Circ Res,2012,111:750-760.
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  • 9Takamiya M, Haider KH, Ashraf M, et al. Identification and characterization of a novel multipotent sub-population of Sea-1+ cardiac progenitor ceils for myocardial regeneration. PLoS One, 2011,6 : e25265.
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二级参考文献51

  • 1罗涛,李玉明.心脏干细胞移植电生理效应及其致心律失常机制[J].武警医学院学报,2007,16(5):576-579. 被引量：2
  • 2Schachinger V, Erbs S, Elsasser A, et al. Intracoronary bone mar- row derivedprogenitor cells in acute myocardial infarction [ J ]. N En- gl J Med,2006,355:1210.
  • 3Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone- marrow cell transfer after myocardial infarction: the BOOST random- ised controlled clinical trial[J]. Lancet,200g,364:141.
  • 4Yousef M, Schannwell CM, Kostering M, et al. The BALANCE Study: clinical benefit and long-term outcome after intracoronary au- tologous bone marrowcell transplantation in patients with acute myo- cardial infarction[J]. J Am Coil Gardiol, 2009,53:2262.
  • 5Strauer BE, Yousef M, Schannwell CM. The acute and long-term effects of intracoronary Stem cell Transplantation in 191 patients with chronic heart failure : the STAR-heart study [ J ]. Eur J Heart Fail, 2010,12:721.
  • 6van Ramshorst J, Bax J J, Beeres SL, et al. Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomizedcontrolled trial [ J ]. JAMA, 2009,301 : 1997.
  • 7Abdel-Latif A, Bolli R, Tleyjeh IM, et al. Adult bone marrow-de- rived cells for cardiac repair: a systematic review and meta-analysis [ J]. Arch Intern Med,2007,167:989.
  • 8Bartunek J, Vanderheyden M, Vandekerckhove B, et al. Intracoro- nary injection of CD133 -positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety [ J ]. Circulation,2005,112.
  • 9Ahmadi H, Baharvand H, Ashtiani SK, et al. Safety analysis and improved cardiac function following local autologous transplantation of CDI33(+) enriched bone marrow cells after myocardial infarction [ J]. Curr Neurovasc Res, 2007,4:153-160.
  • 10Stamm C, Westphal B, Kleine HD, Autologous bone-marrow stem- cell transplantation for myocardial regeneration [ J ]. Lancet, 2003, 361:45.

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中国心血管病研究
2015年 第11期

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