功能性消化不良患者PHQ-15量表的改编及与原量表的比较研究

The adaptation of PHQ-15 scale in functional dyspepsia patients and comparative study of it with the original scale

目的改编患者健康问卷躯体症状群量表(patient health questionnaire-15,PHQ-15),评估功能性消化不良(functional dyspepsia,FD)患者躯体化,并与原量表比较评估其有效性。方法收集315例FD患者,选取阳性率较高的非胃肠道症状15个,形成改编的PHQ-15量表;用PHQ-15、改编的PHQ-15量表评估患者躯体化、症状严重度量表(dyspepsia symptom severity,DSS)评估消化不良症状严重度,并对PHQ-15、改编的PHQ-15进行因子分析、信度分析及其与DSS的相关性。结果改编的PHQ-15四个维度的累积贡献率为52.090%,总量表和4个因子的α值分别为:0.756、0.707、0.624、0.590、0.471;PHQ-15的4个维度累积贡献率为47.069%,总量表和4个因子的α值分别为:0.639、0.529、0.451、0.412、0.444。改编的PHQ-15及PHQ-15与DSS具有相关性(r=0.467,P=0.000;r=0.365,P=0.000)。结论改编的PHQ-15量表的信度及效度可能高于原表,其评估FD患者躯体化与DSS的相关性较原表更好,提示改编的PHQ-15量表对今后更好地评估躯体化对FD的影响可能是有益的。

Objective To adapt Patient Health Questionnaire-15 （PHQ-15） measure somatiztaion in functional dys- pepsia （FD） patients and evaluate the validity of the questionnaire through comparing with original scale. Methods Three hundred and fifteen FD patients with non-gastrointestinal symptoms of FD were collected. Formed adapted PHQ-15 by choosing 15 symptoms which had higher positive rate ; the somatization and dyspepsia were evaluated by PHQ-15, a- dapted PHQ-15 and DSS, respectively. Factor analysis, reliability analysis and correlation analysis with DSS were car- ried out in PHQ-15 and adapted PHQ-15. Results The cumulative contribution of four factors of adapted PHQ-15 was 52. 090% , Cronbach-et coefficient of total scale and four factors were 0. 756, 0. 707, 0. 624, 0. 590, 0. 471, re- spectively. The cumulative contribution of four factors of PHQ-15 was 47. 069% , Crobanch-et coefficient of total scale and four factors were 0. 639, 0. 529, 0. 451, 0. 412, 0. 444, respectively. DSS was associated with somatization meas- ured by adaptedPHQ-15 （r=0.467, P=0.000） and PHQ-15 （r=0.365, P=0.000）.Conclusion The reliability and validity of adapted PHQ-15 may be higher than original scale, and correlation with DSS also better in FD patients, these results suggest that adapted PHQ-15 may be beneficial for measuring the influence of somatization on FD in further studies.