铜促C-H官能团化合成桥头氮稠杂环化合物的研究进展

Progress in the Research of Copper Promoted C-H Functionalizations for the Synthesis of Fused Heterocycles Bearing Bridgehead Nitrogen

归纳论述了铜促C—H官能团化和闭环策略在合成新颖稠杂环化合物中的新发展.这一类桥头氮稠杂环包括氮茚、吡唑并吡啶、吡啶并苯并咪唑等化合物.铜盐催化的现代胺化反应,氧化偶联和Csp2—H、Csp—H、Csp3—H键和N—H活化的联合使用充分体现了这一绿色合成新法的优越性和实用性.对一些复杂的闭环反应机理,进行了总结和概括.

The copper-catalyzed C—H activation, selective functionalization and the development of cyclization strategy for the synthesis of novel fused-heterocyclic（heterocycles with ring-junction nitrogen or bridgehead nitrogen） compounds are discussed. This class of novel bridgehead nitrogen heterocycles includes indolizine, pyrazolopyridine, benzimidazole and other polyheterocyclic compounds. The series including modern amination, oxidative coupling and Csp2—H, Csp—H, Csp3—H and N—H activation catalyzed by Cu（I） or Cu（II） salts makes this green synthesis a superior and practical method providing entry into complex heterocycles. Some reaction mechanisms have also been summarized.