四逆当归方对腹泻型肠易激综合征患者VIP、SS、MOT含量的影响

Effect of Sini Danggui Recipe on VIP,SS and MOT Contents of D- IBS Patients

目的:观察四逆当归方治疗腹泻型肠易激综合征肝郁脾虚证的疗效及对患者血浆VIP、SS、MOT含量的影响。方法:将120例患者随机分为治疗组与对照组。治疗组口服四逆当归方,对照组口服得舒特,两组均服4周为1个疗程,间隔1周后,继服第2个疗程。观察治疗前后临床症状疗效及血浆中胃肠激素VIP、SS、MOT的变化情况。结果:治疗组总有效率为88.33%,优于对照组68.33%。治疗组治疗4周后在改善腹痛腹胀、胸胁胀闷、食欲不振症状上优于对照组(P<0.01或P<0.05);治疗9周后在大便泄泻、腹痛腹胀、郁怒或紧张、食欲不振的改善上优于对照组(P<0.01或P<0.05)。两组治疗4周后,3种胃肠激素的含量均有不同程度的下降,治疗组下降更明显,治疗9周后,除对照组VIP数值上升,其余皆呈下降趋势,但无统计学意义。结论:四逆当归方治疗腹泻型肠易激综合征具有较好的临床疗效,并能调节患者的胃肠激素水平。

Objective： To observe the influence of Sini Danggui Recipe on the clinical curative effect and the dampness on VIP,SS and MOT in patients with diarrhea- predominant irritable bowel syndrome. Methods： 120 cases were randomly divided into treatment group and control group. The treatment group was treated with modified Sini Danggui Recipe. The control group was given Dicetel and 4 weeks were one course of treatment. one week interval later,the second treatment course continued. The clinical curative effect and the plasma gastrointestinal hormone changes of the VIP,SS and MOT were observed before and after treatment. Results： The total efficacy rate of treatment group was 88. 33%,better than the control group＇s 68. 33%. 4 weeks after treatment,the treatment group in improving the abdominal pain and distention,chest and hypochondrium distension and loss of appetite were better than the control group（ P 〈0. 01 or P 〈0. 05）. 9 weeks after treatment,the diarrhea,abdominal pain and distention,distension or nervous and loss of appetite in the treatment group were better than those of control group（ P〈 0. 01 or P 〈0. 05）.4 weeks after treatment,2 groups＇ 3 kinds of gastrointestinal hormone levels all had varying degrees of decline,while treatment group＇s decreased more obviously. 9 weeks after treatment,in addition to the control group＇s VIP increasing,the rest had a downward trend,without statistical significance. Conclusion： Sini Danggui Recipe has good clinical curative effect in treating diarrhea predominant irritable bowel syndrome and can adjust the patients＇ gastrointestinal hormone levels.