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MicroRNA-146与肿瘤 被引量：1

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摘要 微小核糖核酸（microRNA,miRNA）是一类长度约为21～23个核苷酸（nucleotide,nt）的内源性小单链非编码RNA,在机体进化过程中高度保守,通过转录后调节机制参与机体各器官的生物学功能。miRNAs介导的基因表达在维持正常的细胞周期、分化、凋亡、代谢等方面发挥着作用。成熟的miRNA通过完全或不完全互补3＇端UTR片段与靶mRNA结合，其互补性主要取决于miRNA5’端的第2位到第8位核苷酸序列（seed sequence）。
作者 肖文杰 崔德威
机构地区 广东医学院附属医院
出处 《中国临床研究》 CAS 2015年第11期1519-1520,1524,共3页 Chinese Journal of Clinical Research
关键词 微小核糖核酸 微小核糖核酸-146 肿瘤 核因子-ΚB
分类号 R730.2 [医药卫生—肿瘤]
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参考文献21

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二级参考文献37

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中国临床研究
2015年 第11期

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