不同宫颈组织中erbB3、erbB4表达及作用

Expressions of ErbB3 and ErbB4 in Different Cervial Tissues

目的 探讨不同宫颈组织中 erb B3、erb B4表达及其意义。方法 应用免疫组化 HIGH- SABC方法检测了5 0例宫颈鳞癌组织 ,15例中度不典型增生 ,15例正常宫颈上皮组织进行 erb B3、erb B4的表达。结果 在不同宫颈组织中 ,erb B3、erb B4的阳性表达率依次为宫颈鳞癌 >中度不典型增生 >正常宫颈组织 ;erb B3、erb B4表达与宫颈癌细胞的分化程度呈负相关 ,与 FIGO分期呈正相关 ,与其他临床病理参数不相关。结论 erb B3和 erb B4在宫颈癌的发生发展中可能起着重要的作用 ,它们可以预测宫颈癌恶化潜能 ,但不能作为宫颈癌预后的独立评价指标。

Objective To explore the expressions of erbB3 and erbB4 in different ce rvical tissues.Methods Expressions of erbB3 and erbB4 were detected by immunohistochemical staining in 50 cases with squamous cell cervical carcinoma,15 cases of CIN Ⅱ,15 cases of normal cervical epithelium.Results The expression rates of erbB3 and erbB4 protein in different tissues were:squamous cell cervical carcinoma>CIN Ⅱ>normal cervical epithelium. The expressions of erbB3 and erbB4 protein positively correlated with FIGO stage and negatively correlated with cell differentiation.There were no significant correlation between the expressions of erbB3 and erbB4 and prognosis of cervical carcinoma.Conclusion erbB3 and erbB4 protein might play an important role in genesis and development of cervical carcinoma.erbB3 and erbB4 could predict malignant potentiality,but they couldn't be viewed as independent prognostic marker to evaluate cer vical carcinoma.