非布司他对急性痛风性关节炎患者氧化应激的影响

Effect of febuxostat on oxidative stress in the treatment of patients with acute gouty arthritis

目的 :探讨非布司他治疗急性痛风性关节炎对患者血清尿酸(SUA)水平及氧化应激的影响。方法 :选取2014年2月-2015年5月我院门诊收治的未经降尿酸治疗的急性痛风性关节炎患者87例,按随机数字表法分为观察组(n=45)和对照组(n=42),分别给予非布司他80 mg/d和别嘌呤醇300 mg/d,口服治疗,3次/d,疗程为24周。比较两组患者治疗期间SUA水平及氧化应激标志物8-羟基脱氧鸟苷(8-OHd G)和3-硝基络氨酸修饰蛋白(3-NT)水平的变化。结果 :与治疗前相比,两组患者治疗后SUA、8-OHd G均明显降低(P<0.05),而3-NT无显著性差异(P>0.05),组间SUA、8-OHd G变化幅度比较,差异无统计学意义(P>0.05);Spearmen相关性分析,8-OHd G水平与SUA呈明显正相关(r=0.620,P<0.05)。结论 :非布司他可有效降低急性痛风性关节炎患者SUA水平,改善患者氧化应激状态,可广泛应用于临床。

Objective： To discuss the effect of febuxostat on serum uric acid（SUA） levels and oxidative stress in the treatment of patients with acute gouty arthritis.Methods： Eighty-seven cases of patients with acute gouty arthritis were selected and randomly divided into an observational group （n=45） and a control group （n=42）, 80 mg/d of febuxostat was given in the observational group and 300 mg/d of allopurinol in the control group by oral, tid for 24 weeks. The changes of SUA, 8-OHdG, 3-NT levels were compared between two groups.Results： The serum levels of SUA and 8-OHdG in all patients were signiifcantly lower after treatment than before （P＜0.05）, and there was no signiifcant difference in 3-NT levels （P＞0.05）. The comparison of the changes of serum levels of SUA and 8-OHdG showed no signiifcant difference between two groups （P＞0.05）. The analysis of Spearmen correlation showed that 8-OHdG was positively correlated with SUA（r=0.620,P＜0.05）.Conclusion： Febuxostat can effectively reduce the SUA levels of patients with acute gouty arthritis, improve the state of oxidative stress and can be widely used in clinic.