伊贝沙坦对急性心肌梗死后左室重塑影响

Effects of Irbesartan on the Left Ventricular Remodeling Following Acute Myocardial Infarction

目的 观察伊贝沙坦对急性心肌梗死 (AMI)后左室重塑的阻抑作用。方法 将 72例 AMI患者随机分为常规治疗组 36例、伊贝沙坦治疗组 36例 ,并于 AMI后 2、2 4周分别进行超声心动图和平衡法核素心室造影 ,测定左室心肌重量、左室收缩功能和舒张功能 ,了解伊贝坦对 AMI后左室重塑的阻抑作用。结果 AMI后 2 4周时伊贝沙坦与常规治疗组比较室间隔厚度、左室后壁厚度、左室舒张末内径和左室心肌重量指数均明显降低 (P<0 .0 5 ,或 P<0 .0 0 1)。AMI后 2 4周时 ,伊贝沙坦治疗组与对照组比较左室射血分数明显增加 (P <0 .0 5 ) ,左室峰射血率和左室峰射血率时间均显著下降 (P<0 .0 5 ) ,同时左室高峰充盈率明显升高 (P<0 .0 5 ) ,左室高峰充盈率时间显著下降 (P<0 .0 0 1)。结论 伊贝沙坦能明显减轻心肌梗死后心肌肥厚和左室重塑 ,改善左室功能。

Objective To observe the inhibitory effects of irbesartan on left ventricular remodeling(LVRM)after acute myocardial infarction(AMI) Methods 72 patients with AMI were randomized divided into the conventional treatment group(36 patients) and irbeasartan treatment group(36 patients).At 2nd and 24th week after AMI,the left ventricular myocardium weight were measured by echocardiogram,and the parameters of left venticular systolic and diastolic function were measured by equilibrium radionuclide angiography.Results At 24th week,LVEF,LPER and LPFR in irbesartan treatment group were significantly increased(P<0.05)as comared with those in conventional treatment group,res pectively.LTPER and LTPFR in irbesartan group were decreased (P<0.05,or P<0.001) as compared with the conventional treatment group,respectively.Conclusion Irbesartan could significantly reduce myocardial hypetrtophy and LV RM following AMI,thus improve the left ventricular systolic function.