原发性肝癌患者维生素D受体的表达和意义

EXPRESSION AND SIGNIFICANCE OF VITAMIN D RECEPTOR IN PATIENTS WITH PRIMARY HEPATIC CARCINOMA

目的:通过检测原发性肝癌患者维生素D受体(VDR)蛋白的表达,探讨原发性肝癌VDR的表达和意义。方法:采用蛋白免疫印迹法检测105例原发性肝癌患者和100例健康体检者外周血单个核细胞VDR蛋白的表达情况。结果:原发性肝癌患者VDR蛋白的表达水平明显低于健康体检者(P<0.05)。原发性肝癌患者VDR蛋白表达与性别、年龄、AFP、肿瘤直径无关(P>0.05);与肝功能Child-Pugh分级有关,A级、B级患者VDR蛋白的表达水平明显高于C级患者(P<0.05)。结论:VDR蛋白低表达可能是原发性肝癌的不利因素。

Objective： To investigate the expression and signifi cance of vitamin D receptor（VDR） in patients with primary hepatic carcinoma. Methods： Western blot was used to detect the expression of VDR protein in peripheral blood mononuclear cells of 105 primary hepatic carcinoma patients and 100 healthy controls. Results： The VDR protein expression level of primary hepatic carcinoma patients was obviously lower than that of healthy controls（P〈0.05）. For primary hepatic carcinoma patients, the VDR protein expression was irrelevant to sex, age, AFP and size of tumour（P〉0.05）; but related to liver function child-pugh classifi cation（P〈0.05）. Conclusions： Low expression of VDR protein maybe unfavorable factors of primary hepatic carcinoma.