低钠血症对小细胞肺癌预后影响的研究进展

Influence of Hyponatremia on the Prognosis of Small Cell Lung Cancer

低钠血症是小细胞肺癌（SCLC）临床最常见的电解质紊乱，其发生机制目前主要是认为肿瘤细胞分泌及相关药物的应用引起体内抗利尿激素增多而导致的抗利尿激素分泌异常综合征（SIADH）。SIADH是小细胞肺癌重要的副肿瘤综合征，它的临床表现因低钠血症的程度不同而有所不同，目前已有相关研究指出低钠血症的程度可能与肿瘤的大小或攻击性有关，如果这是真的，那我们就可以用低钠血症筛查高危个体可以产生更多的可能的肺癌患者。

Hyponatremia is the most common clinical electrolyte disorder in the patients with small cell lung cancer which the main mechanism is abnormal secretion of antidiuretic hormone （SIADH） caused by the antidiuretic hormone increasing in the body be- cause of the tumor cells secreting and the application of related drugs. SIADH is the important paraneoplastic syndrome of small cell lung cancer, which clinical manifestations are different according to the degree of hyponatremia. At present the research has showed that the degree of hyponatremia may be associated with the size of the tumor. If it is true hyponatremia screening can be used in the dignosis of lung cancer patients.