钯催化炔碘与有机锡化合物交叉偶联反应

Palladium-catalyzed cross-coupling reaction of alkynyl iodides with organotin compounds

以钯为催化剂,DMEDA为配体,实现了碱性条件下炔碘化合物与有机锡化合物的Stille交叉偶联反应,合成了一系列芳环上含有甲基、甲氧基及卤原子的中间炔烃。该方法底物适应范围广、产率高,为C—C键的构筑提供了一条新路径。

Palladium-catalyzed Stille cross-coupling reaction of alkynyl iodides and organotin compounds was developed under alkaline conditions,with DMEDA as ligand,which synthesized a series of internal alkynes including Me,Me O and halogen functional groups on the aromatic ring. The method had advantages of wide range of substrates and high yields,which provided a new route for the construction of C—C bond.