摘要
目的:制备壳寡糖接枝布洛芬(COS-g-IBU)纳米粒负载羟基喜树碱(HCPT)纳米粒,并考察其体外释药性能。方法:以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC)为偶联剂,制备壳寡糖接枝布洛芬纳米粒(COS-g-IBU NPs)。以COS-gIBU NPs为载体,使用超声振荡技术制备负载HCPT的壳寡糖接枝布洛芬纳米粒(HCPT-COS-g-IBU NPs)。结果:透射电镜照片显示COS-g-IBU NPs和HCPT-COS-g-IBU NPs为球形,平均粒径分别为(116±2)nm和(146±5)nm,测得药物包封率为(79.24±1.18)%,载药量为(3.62±0.05)%,体外药物释放试验表明HCPT-COS-g-IBU NPs具有明显的缓释作用。结论:COS-g-IBU可作为HCPT缓释载体材料。
OBJECTIVE To prepare chitosan-oligosaccharide-graft-ibuprofen（ COS-g-IBU） loaded with 10-hydroxycamptothecin（ HCPT）,and investigate its in vitro release properties. METHODS Chitosan oligosaccharide grafted ibuprofen nanoparticles（ COSg-IBU NPs） was synthesized with 1-（ 3-dimethylaminopropyl）-3-ethyl-carbodiimide hydrochloride（ EDC） as coupling agent. HCPTCOS-g-IBU NPs were prepared by ultrasonic irradiation technology. RESULTS TEM images showed that COS-g-IBU NPs and HCPTCOS-g-IBU NPs were spheres with mean sizes of（ 116 ± 2） nm and（ 146 ± 5） nm,respectively. Encapsulation efficiency of nanoparticles was up to（ 79. 24 ± 1. 18） %; and the drug loading was（ 3. 62 ± 0. 05） %. CONCLUSION COS-g-IBU can be used as a sustained release carrier material for HCPT.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2015年第21期1910-1914,共5页
Chinese Journal of Hospital Pharmacy
基金
河北省自然科学基金--石药集团医药联合研究基金优先资助项目(编号:H2013209192)
关键词
羟基喜树碱
壳寡糖
布洛芬
纳米粒
10-hydroxycamptothecin
chitosan oligosaccharide
ibuprofen
nanoparticles
