摘要
目的:初步探讨非罗伯逊型复发性t(11;22)(q23;q11)染色体平衡易位的发生机制。方法:外周血染色体核型分析检测有不孕不育或不良生育史的4例患者的染色体核型。结果:4例t(11;22)(q23;q11)易位患者,染色体断裂位点一致,患者间无亲缘关系,均有不良生育史,其中2例女性表现为反复流产,2例男性患者表现为精子数目减少和活力下降的。结论:t(11;22)(q23;q11)是一种较为少见的非罗伯逊易位型复发性平衡易位,对t(11;22)(q23;q11)深入研究有助于进一步完善染色体畸变的理论基础。
Objective: To discuss the mechanism of recurrent non-Robertsonian balanced chromosomal translocation oft(11 ;22)(q23;q11). Methods: Chromosome karyotype for peripheral blood was performed on patients with infertility or abnormal pregnancy histories. Results: Four unrelated patients were shown to carry t(11 ;22)(q23; q11) translocation with almost identical breakpoints. The two females presented with repeated abortions and the two males had low level of sperm count and activities. Conclusion: t(11 ;22)(q23 ;q11) is a less common type of recurrent non-Robertsonian balanced translocation. Intensive studies of t(11 ;22)(q23 ;q11) are helpful to further improve and complete our knowledge in understanding the theoretical basis of chromosomal aberrations.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2015年第11期776-780,共5页
Reproduction and Contraception