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环状RNA:潜在的新型miRNA活性调控分子 被引量：7

Circular RNA: Potential New Type of miRNA Active Regulatory Molecules
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摘要 环状RNA(circular RNA,circRNA)是近年来RNA领域最新的研究热点.它是一类由特殊的选择性剪切产生且在真核细胞中广泛表达的环形内源性RNA分子.研究发现,circRNA富含microRNA(miRNA)结合位点,可以发挥竞争性内源RNA作用,作为miRNA"海绵"来解除对其靶基因的抑制效应.近年来,circRNA作为一种新型调控分子调控miRNA功能的发挥,受到众多研究者的青睐.本文综述circRNA的产生机制,及其调控miRNA的最新研究进展与研究方法等. Circular RNA（ circRNA） is a recent addition to the growing list of types of noncoding RNA.In recent years,circRNA analysis has been the latest popular research in RNA fields. It is a kind of circular endogenous RNA molecules produced by special selectivity of shear and widely expressed in eukaryotic cells. Recent studies have revealed thousands of endogenous circRNAs in mammalian cells,some of which are highly abundant and evolutionarily conserved. Evidence is emerging that some circRNAs might regulate microRNA（ miRNA）,because of circRNA containing many miRNA binding sites,which can play a role as competitive endogenous RNA（ ceRNA） and as the miRNA ＂sponge＂to remove the inhibition effect of the target genes. Now,many scientists are interested in its function of miRNA ＂ sponge ＂. Therefore, in order to attract more researchers ＇ attention, the circularization mechanism, the latest progress of potential regulation of miRNA, and the research methods were summarized in this paper.
作者 张燕燕 任国诚 张晾
机构地区 山东师范大学生命科学学院山东省动物抗性生物学重点实验室
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2015年第11期1158-1163,共6页 Chinese Journal of Biochemistry and Molecular Biology
基金 国家自然科学基金(No.81100193) 教育部高等学校博士学科点专项科研基金(新教师类)(No.20113704120006)~~
关键词 环状RNA 竞争性内源性RNA 微RNA circular RNA competing endogenous RNA microRNA
分类号 Q522 [生物学—生物化学]
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参考文献37

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二级参考文献33

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共引文献13

同被引文献134

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  • 4Jeck W R, Sorrentino J A, Wang K, et al. Circular RNAs are abundant, conserved, and associate-d with ALU repeats. RNA,2013, 19(2): 141–157.
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  • 7Cocquerelle C, Mascrez B, Hetuin D, et al. Mis-splicing yields circular RNA molecules. FASEB Journal,1993, 7(1): 155–160.
  • 8Wilusz J E, Sharp P A. Molecular biology:A circuitous route to noncoding RNA. Science,2013, 340(6131): 440–441.
  • 9Wu Q, Wang Y, Cao M, et al. Homology-independent discovery of replicating pathogenic circular RNAs by deep sequencing and a new computational algorithm. Proc Natl Acad Sci USA,2012, 109(10): 3938–3943.
  • 10Lu T T, Cui L L, Zhou Y, et al. Transcriptome-wide investigation of circular RNAs in rice. RNA,2015, 21(12): 2076–2087.

引证文献7

二级引证文献32

中国生物化学与分子生物学报
2015年 第11期

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