摘要
目的探究胱抑素C、同型半胱氨酸在心力衰竭患者中的表达情况及其诊断价值。方法将2009年1月—2012年12月在我院就医的72例慢性心力衰竭患者作为实验组,另外选取52例健康成人作为对照组,分别检测两组患者的胱抑素C水平、同型半胱氨酸水平及左室射血分数并进行比较。结果实验组患者治疗后与治疗前相比,胱抑素C、同型半胱氨酸表现出显著性差异(P<0.05),而左室射血分数无显著差异(P>0.05);实验组治疗后与对照组相比,胱抑素C、同型半胱氨酸及左室射血分数均有显著性差异(P<0.05);胱抑素C、同型半胱氨酸随患者心力衰竭分级不同而表现出显著性差异(P<0.05);胱抑素C水平与同型半胱氨酸水平呈正相关,且两者均与左室射血分数呈负相关。结论胱抑素C及同型半胱氨酸水平与患者病情严重程度成正比,两者可以反映心功能状态,在早期心力衰竭的诊断中具有重要意义。
Objective To investigate the expression and diagnostic value ofcystatin C （CysC） and homocysteine in patients with heart failure. Methods Seventy-two patients with chronic heart failure who were admitted to our hospital from January 2009 to December 2012 were assigned into the experimental group. Additional 52 patients were assigned into the control group. For patients in both groups, levels of CysC, homocysteine and the left ventricular ejection fraction （LVEF） were detectived and compared. Results For patients in the experimental group there were significant differences in levels of CysC and homocysteine before and after treatment （P〈0.05）, but with no significant difference in LVEF （P〉0.05）. There were significant differences in levels of CysC and homocysteine and LVEF between both groups after treatment （P〈0.05）. Levels of CysC and homocysteine varied significantly with stages of heart failure in patients （P〈0.05）. The CysC level was positively correlated with the homocysteine level, and they both were negatively correlated with LVEF. Conclusion Levels of CysC and homocysteine are proportional to the patient＇s disease severity. They both can reflect the cardiac function status and has important significance in early diagnosis of heart failure.
出处
《国外医药（抗生素分册）》
CAS
2015年第6期276-278,共3页
World Notes on Antibiotics
