β-catenin的翻译后修饰及其作用

Research Progress of β-catenin Post-Translational Modification and its Function

β-catenin是一种进化上保守的多功能蛋白质,不但可与上皮型钙黏蛋白(E-cadherin)结合形成复合体参与细胞间连接,维持上皮细胞的正常形态结构,而且参与Wnt信号通路,作为其中的关键环节,调控基因转录,在胚胎发育、肿瘤发生和侵袭转移等生理病理过程中扮演举足轻重的角色.因此,对β-catenin的调节就显得尤为重要,在众多调节机制中,β-catenin的翻译后修饰对其发挥功能有着重要作用.本文对β-catenin不同位点的修饰及其调控酶的研究进展做简要综述.

β-catenin is an evolutionary conserved multifunctional protein, not only with the epithelial cadherin（E-cadherin） combine to form a complex involved in intercellular connections, maintain the normal morphology of epithelial cells, but also as the activation of Wnt signaling pathway in core areas, it plays a critical role in a series of physiological and pathological processes, such as embryogenesis, tumor development, invasion and metastasis. Therefore, the regulation of β-catenin is very important, post-translational modification is an important regulation mechanism of β-catenin. This paper presents a brief review for the research progress of β-catenin post-translational modification and the enzymes.