角蛋白与结直肠癌相关性研究进展

Correlation research progress of keratin and colorectal cancer

目的总结角蛋白与结直肠肿瘤相关的研究现状,以及在结直肠肿瘤诊断、治疗及预后中的作用。方法应用PubMed、万方、维普及CNKI全文数据库检索系统,以"角蛋白(Keratin)、结直肠癌(Colorectal cancer)和肿瘤标志物(Tumor markers)"为关键词,检索2010-01-2014-03的相关文献,共151篇英文文献和46篇中文文献。纳入标准:1)角蛋白的生物活性及其生理功能;2)角蛋白的异常表达对结直肠癌发生发展的影响;3)结直肠癌的诊断、治疗、转移及其预后与角蛋白的相关性。根据纳入标准符合分析的文献36篇。结果 K7、K8、K18和K20等在结直癌肠组织中表达丰富,其表达变化与结直肠癌的发生、发展及其预后密切相关;K7、K19和K20的表达及分布异常与结肠癌的预后和转移有关;角蛋白18凋亡切割片段可以用来检测肿瘤对治疗的反应,并成为评估结直肠癌患者预后的指标。结论角蛋白的表达异常在结直肠肿瘤的发生发展中具有重要作用;角蛋白有望成为结直肠癌患者淋巴结转移诊断、治疗及其预后监测和评估的肿瘤标志物。

OBJECTIVE To sum up the related research association between colorectal cancer with keratin and the role of keratin in the diagnosis, treatment and prognosis of colorectal cancers. METHODS Totally 151 English articles and 46 Chinese articles were searched by ＂Keratin, Coloreetal cancer, Tumor markers＂ as keywords in PubMed, Wan Fang Data, VIP Paper Cheek System and CNKI databases from Jan. 2010 to Mar. 2014. Totally 36 papers were selected and analyzed according to the inclusion criteria as follows： biological activities of keratin and its physiological function. The abnormal expression of keratin and its mecha- nisms of the influence on the occurrence and development of colorectal cancer. The relationship between keratin and the diagnosis, treatment, transfer and prognosis of colorectal cancer. RESULTS K7, K8, K18 and K20 are abundantly expressed in eolorectal tissues, and the changes of their expression are closely related to the occurrence, development and prognosis of colorectal cancer. the abnormal expression and distribution of K7, K19, K20 have relationships with the prognosis and metastasis of colon cancer. the apoptotic cleavage fragment of keratin 18 can be used to detect the response to therapy of tumor and to evaluate the prognosis of patients with colorectal cancer. CONCLUSIONS The abnormal expression of keratin plays an important role in the occurrence and development of colorectal cancer. And keratin maybe as a marker of tumor to participate in the diagnosis and treatment of lymph node metastasis of coloreetal cancer patients and the monitoring and evaluation of prognosis of colorectal cancer.