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抗小泛素样修饰物活化酶抗体阳性皮肌炎一例

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摘要 患者女,58岁,主因＂干咳、颈面部皮疹1个月,肌无力伴发热1周＂于2012年6月入院.患者1个月前无明显诱因始出现干咳,伴轻度活动后气促,未就诊.随后出现额部、面部及前胸部、颈部红色皮疹,伴轻度瘙痒,于当地医院就诊,考虑＂肺炎＂,予以头孢呋辛抗感染治疗后,皮疹较前有所消褪,但仍有间断干咳.1周前出现四肢肌痛、肌无力,下蹲后起立困难,间断发热,体温最高38.5℃,可自行降至正常.伴吞咽困难,仅能进食半流质食物.入院查体见颜面部及前胸部可见暗红色陈旧性皮疹.
作者 陈智勇 胡伟 孔祥怡 王燕 桑名正隆 孙凌云
机构地区 南京大学医学院附属鼓楼医院风湿免疫科 南京大学医学院附属鼓楼医院检验科 南京大学医学院附属鼓楼医院妇产科 南京医科大学研究生院 日本医科大学变态反应与风湿科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2015年第11期769-770,共2页 Chinese Journal of Rheumatology
基金 国家自然科学基金（81302556） 江苏省科技厅青年基金（BK20130087）
关键词 抗体阳性 皮肌炎 活化酶 修饰物 红色皮疹 泛素 医院就诊 间断发热
分类号 R593.26 [医药卫生—内科学]
  • 相关文献

参考文献9

  • 1陈智勇,胡伟,郭子维,王燕,曹孟淑,孙凌云.抗核基质蛋白2抗体阳性多发性肌炎/皮肌炎七例临床分析并文献复习[J].中华风湿病学杂志,2014,18(12):810-814. 被引量：5
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  • 4Betteridge ZE, Gunawardena H, Chinoy H, et al. Clinicaland human leucocyte antigen class II haplotype associations ofautoantibodies to small ubiquitin-like modifier enzyme, a der-matomyositis-specific autoantigen target, in UK Caucasian adult-onset myositis[J]. Ann Rheum Dis, 2009, 68( 10): 1621-1625.
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  • 7Bodoki L,Nagy-Vincze M, Griger Z, et al. Four dermatomyosi-tis-specific autoantibodies-anti-TIF 1 gamma, anti-NXP2, anti-SAE and anti-MDA5-in adult and juvenile patients with idiopath-ic inflammatory myopathies in a Hungarian cohort[J]. AutoimmunRev, 2014, 13(12): 1211-1219.
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  • 9Betteridge ZE, Gunawardena H, McHugh N J. Novel autoanti-bodies and clinical phenotypes in adult and juvenile myositis [J].Arthritis Res Ther, 2011, 13(2): 209-215.

二级参考文献15

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共引文献5

中华风湿病学杂志
2015年 第11期

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