胰腺癌与糖尿病的相关性及其影像学评价

The correlation between diabetes and pancreatic cancer and the imaging findings

目前研究显示糖尿病和胰腺癌密切相关,糖尿病可能是胰腺癌发生发展的高危因素,亦或是胰腺癌的早期临床表现,但两者具体关系仍不明确。因此,探究胰腺癌与糖尿病的相关性及其分子机制对两者的诊断及治疗具有重要意义。同时,常规影像技术及分子影像技术可对胰腺癌和糖尿病发生发展过程中的异常进行评价。文中将对胰腺癌和糖尿病之间的相关性及其可能相互分子机制,如高血糖、胰岛素样生长因子(insulin-like growth factors,IGF)、氧化应激、胰岛淀粉样多肽(islet amyloid polypeptide,IAPP)及Kruppel样因子Ⅱ基因突变等作一综述。

Diabetes mellitus（ DM） is widely considered to be associated with pancreatic cancer（ PC）. Some studies have shown that DM has been recognized as a risk factor for PC and the early clinical manifestation of PC,however the exact relationship remains unclear. The conventional imaging techniques and molecular imaging techniques can evaluate the abnormal condition during the occurrence and development of PC and diabetes. This article will review the correlation between PC and DM and the potential molecular mechanism,such as hyperglycemia,insulin-like growth factors,oxidative stress,islet amyloid polypeptide and Kruppel sample factorⅡ gene mutations,etc. In addition,the value of imaging diagnosis for PC and DM is also reviewed.