^(125)I放射性粒子植入联合GP加重组人血管内皮抑素治疗老年晚期非小细胞肺癌临床研究

The Clinical Study of Radioactive ^(125)I Seeds Implantation Combined with GP and Rh-endostatin in the Treatment of Elderly Patients with Advanced Non-small Cell Lung Cancer

目的:探讨125I放射性粒子联合GP加重组人血管内皮抑素(恩度)方案治疗老年晚期非小细胞肺癌(NSCLC)的临床疗效。方法:46例初治经临床影像学及病理学检查确诊为Ⅲb~Ⅳ期NSCLC老年患者,研究组24例在CT引导下行瘤体内125I粒子植入,3 d后予GP加恩度方案;对照组22例给予GP方案加恩度方案,治疗4周期后进行疗效评价。结果:研究组和对照组局部控制率、总有效率分别为83.33%和63.64%、70.83%和45.45%,差异均有统计学意义(P<0.05),两组骨髓抑制和胃肠道反应比较差异无统计学意义(P>0.05)。结论:125I粒子植入联合GP加恩度方案治疗老年晚期NSCLC患者,可明显改善患者生活质量,近期疗效显著,是一种安全有效的治疗方法,值得临床推广应用。

Objective： To research the Clinical efficacy of 125I seeds combined with GP and rh-Endostatin in the treatment of elderly patients with advanced non-small cell lung cancer.Method： 46 cases of newly diagnosed by clinical radiologieal and pathological examination confirmed Ⅲb- Ⅳ of non-small cell lung cancer in elderly patients, the study group 24 cases in CT-guided intratumoral 125I seeded implantation, 3 d after to GP and Rh- endostatin program; the control group of 22 patients used GP and Rh-endostatin programs, the efficacy was evaluated after administration of 4-cycle assessment.Result： The study group and the control group of local control rate, the total effective rate were as follows 83.33% and 63.64%, 70.83% and 45.45%, both of which were statistically significant（P〈0.05）, two groups of bone marrow suppression and gastrointestinal reactions difference had no statistically significant（P〉0.05）.Conclusion： 125I seeds implantation combines with GP and rh-Endostatin in the treatment of elderly patients with advanced non-small cell lung cancer which can improve the living quality, the recent effect is significant effect, it is a safe and effective method of treatment, worthy of clinical application.