慢性阻塞性肺疾病与2型糖尿病相关性研究

The Correlation between Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus

目的:通过测定CRP、IL-8、TNF-α水平,探讨其在慢性阻塞性肺疾病(COPD)合并2型糖尿病(T2DM)相关性中的意义。方法:选取COPD患者、COPD合并T2DM患者、健康体检者各30例,测定外周血CRP、IL-8、TNF-α。结果:COPD合并T2DM患者血清CRP、IL-8、TNF-α水平高于COPD患者及健康体检者,差异有统计学意义(P<0.05);COPD患者CRP、IL-8、TNF-α水平高于健康体检者,差异有统计学意义(P<0.05)。结论:CRP、IL-8、TNF-α共同参与了COPD和T2DM的病理生理过程,两种疾病存在一定的相关性,监测炎症因子的水平变化有助于预测COPD患者合并T2DM的危险性。

Objective： To investigate the levels of CRP, IL-8, TNF-α in the patients with COPD complicated T2DM and to analyze relating factors.Method： 30 COPD patients, 30 COPD complicated T2DM patients and 30 healthy volunteers were selected and the serum CRP, IL-8, TNF- α were measured.Result： The serum levels of CRP, IL-8 and TNF-α in the patients with COPD complicated T2DM were significantly higher than the patients with the COPD and the healthy volunteers（P〈0.05）.The levels of CRP, IL-8 and TNF- α in patients with COPD were significantly higher than healthy volunteers（P〈0.05）.Conclusion： CRP, IL-8, TNF- α play a potential role in the pathophysiological processs of COPD and T2DM, indicate a strong correlation between COPD and T2DM.