小茴香代茶饮对妇科恶性肿瘤术后肠道功能恢复的研究

The Effect of Fennel Tea Drinking on Postoperative Gut Recovery after Gynecological Malignancies Operation

目的探索小茴香代茶饮对妇科肿瘤患者腹部手术后肠道功能恢复的影响。方法前瞻性纳入159例妇科恶性肿瘤经腹手术患者,随机分为试验组（n=78）和对照组（n=81）。试验组予术后第1d晨开始口服小茴香代茶饮（小茴香5g＋沸水130mL）,2次/d,至首次肛门排气,对照组予同时口服等量温水。采集术后肠功能恢复情况和并发症指标,比较两组间的差异,同时观察患者对小茴香代茶饮的耐受情况。结果本研究所有纳入患者均能良好耐受小茴香代茶饮。试验组与对照组相比,术后首次排气时间〔（53.1±11.3）h vs.（64.2±13.6）h,P〈0.001）〕、首次排便时间〔（4.3±1.0）d vs.（5.4±1.2）d,P〈0.001）〕和术后住院日〔（5.6±1.2）d vs.（6.7±2.0）d,P〈0.001）〕均缩短。对照组肠梗阻发生率较试验组明显增加〔相对危险度为2.6,95%置信区间为1.5~4.5,P=0.001〕。结论小茴香代茶饮可促进妇科恶性肿瘤患者术后肠功能恢复,减少并发症,并且安全耐受。

Objective To reveal if whether fennel fruit（Fructus Foeniculi）tea drinking enhances the recovery of intestinal function after gynecologic malignancies operation.Methods A total of 159 patients undergoing laparotomy for gynecological cancers were randomized into a tea group（n=78）and a control group（n=81）.The patients in tea group drank a cup of fennel fruit tea while patients in control group drank the equal quantity of water twice per day from the first morning after operation until the first flatus.Every cup of tea consists of 5gram of dried fennel fruit and 130 mL boiled water.The patents only drank the filtrate.Groups were compared in terms of time to first flatus and defecation,postoperative hospital stay,length of parenteral nutrition,ileus symptoms and other postoperative complications.Results Postoperative hospital〔（5.6±1.2）d vs.（6.7±2.0）d,P〈0.001〕,the mean time to flatus〔（53.1±11.3）h vs.（64.2±13.6）h,P〈0.001）〕,and the mean time to defecation〔（4.3±1.0）d vs.（5.4±1.2）d,P〈0.001）〕were significantly lower in tea group compared with those in control group.Ileus symptoms were observed more in patients in the control group compared to patients in tea group 〔relative risk=2.6;95%confidence interval,1.5-4.5;P=0.001 〕.Conclusion Fennel tea drinking after laparotomy for gynecological malignancis,an economical care,is safe,well to lerated and associated with rapider recovery of bowel motility,shorter hospital stay and fewer complications.