血清AFP和AFP-L3检测对原发性肝癌诊断的临床价值

目的探讨血清甲胎蛋白(AFP)和甲胎蛋白异质体L 3(AFP-L 3)联合检测对原发性肝癌(primary hypitic careinoma,PHC)的诊断价值。方法应用化学发光免疫技术对52例原发性肝癌患者、50例良性肝病患者、50例正常人的血清标本进行AFP和AFP-L 3定量检测,并检测肿瘤大中小时血清中两种标志物的不同水平,分析对原发性肝癌诊断的特异性和敏感性。结果原发性肝癌组血清AFP和AFP-L 3的水平明显高于良性肝病组和正常对照组(P<0.05),特别是AFP-L 3在肿瘤早期有较强的的敏感性,其百分比与AFP含量不相关(r=0.18,P>0.05)。结论 AFP和AFP-L 3联合检测对原发性肝癌有较高的诊断价值,尤其可提高早期原发性肝癌的诊断率。

Objective To investigate the Clinical value of the detection of AFP and AFP-L 3 in the diagnosis of liver cancer. Methods Use chemoluminescence method to test AFP and AFP-L 3 of 52 patients with PHC（primary hypitic careinoma）, 50 patients with begin desease and 50 noraml subjests, and the different levels of the two tumor markers in every stadge of the tumor, analyse the specificity and sensitivity. Resu Its The levels of AFP and AFP-L 3 of 52 patients with PHC were higher than the patients with begin desease, in particular AFP-L 3 has better the sensitivity in the early cancer, and the percentage was irrelevant to AFP（r=0.18, P〉0.05）. Conclusion The combine detection of AFP and AFP-L 3 has great clinical valua in the diagnoise of liver cancer, it could develop the diagnoise in the early cancer.