血浆同型半胱氨酸干预与脑出血迟发性脑水肿发生几率的关系研究

目的探讨血浆同型半胱氨酸干预与脑出血迟发性脑水肿发生几率的关系。方法选取77例脑出血伴有高同型半胱氨酸血症患者分为治疗组和对照组,对照组采用常规治疗,治疗组在对照组的基础上,在患者发病后48 h予以叶酸2.5 mg,1次/d,口服。观察2组患者入院后1个月内同型半胱氨酸变化情况,及脑出血迟发性脑水肿的发生几率。结果治疗前治疗组患者的同型半胱氨酸与对照组比较,差异无统计学意义,治疗后治疗组的数值显著低于对照组,差异具有统计学意义(P<0.05)。另外,治疗组治疗后同型半胱氨酸数值显著低于治疗前,治疗前后比较,差异具有统计学意义(P<0.05),对照组治疗前后同型半胱氨酸数值变化不大,治疗前后比较,差异无统计学意义。治疗组发生迟发性脑水肿的病例显著低于对照组,差异具有统计学意义(P<0.05)。结论用叶酸干预同型半胱氨酸治疗效果显著,而且同型半胱氨酸指标的降低可以减少脑出血迟发性脑水肿发生的几率。

Objective To discuss the relationship between plasma homocysteine intervention and cerebral hemorrhage of late-onset of cerebral edema. Methods To select 77 cases of patients of cerebral hemorrhage associated with high homocysteine levels, and divided into the experimental group and the control group, the control group was given conventional therapy, the experimental group of patients 48 h after the sick were given once folic acid 2.5 mg orally on the basis of the control group. To observe two groups of patients admitted to hospital after a month of homocysteine changes, and the risk of cerebral hemorrhage of late-onset cerebral edema. Results Patients of homocysteine between the treatment group and the control group had not significant difference before treatment, the treatment group of numerical had significantly lower than the control group after treatment, the difference had statistical significance （P 〈 0.05）. In addition, the treatment group of homocysteine numerical after treatment had significantly lower than before treatment, and it had statistical significance difference, the control group before and after treatment of homocysteine numerical change was not big, the difference had not statistical significance. Happened late cases of cerebral edema therapy group was obviously lower than the control group, the difference had statistical significance （P 〈 0.05）. Conclusion Treatment with folic acid homocysteine intervention effect is obvious, and lower homocysteine index can reduce the risk of cerebral hemorrhage of late-onset brain edema occurred.