血清降钙素原与血培养联合检测对血流感染的诊断价值

Value of detection of serum procalcitonin combined with blood culture in diagnosis of bloodstream infections

目的分析血清降钙素原(PCT)与血培养联合检测对血液感染的诊断价值,为临床诊断治疗提供参考。方法选取2013年1-6月医院收治的120例肺炎发热患者为观察组,80例肿瘤发热患者为对照组,入院后对两组患者进行血清PCT测定及血培养,对比检测结果;对观察组患者分别在发热后12、24、48h检测血清PCT并进行血液培养,对比结果。结果首次采血检测,血清PCT检测观察组阳性67例、对照组阳性8例,差异有统计学意义(χ2=43.02,P<0.01),血培养观察组阳性12例、对照组1例,差异有统计学意义(χ2=6.05,P<0.05);观察组患者发热后12、24h,血清PCT阳性61、68例,阳性率50.8%、56.7%,血培养阳性16、31例,阳性率13.3%、25.8%,差异均有统计学意义(P<0.01);发热后48h,血清PCT阳性71例,阳性率59.1%,血培养阳性68例,阳性率56.6%,差异无统计学意义。结论血清降钙素原联合血培养对于诊断血流感染有一定的价值,应在临床工作中加以推广。

OBJECTIVE To analyze the value of detection of serum procalcitonin （PCT） combined with blood culture in diagnosis of bloodstream infections so as to provide guidance for clinical diagnosis and treatment .METHODS To‐tally 120 pneumonia patients with fever who were treated in the hospital from Jan 2013 to Jun 2013 were chosen as the observation group ,and 80 tumor patients with fever were assigned as the control group .The serum PCT level was determined and the blood culture was performed for the two groups of patients after the admission to the hos‐pital ,and the results were compared .The levels of serum PCT of the patients in the observation group were detec‐ted at 12 ,24 ,and 48 hours after they had fever ,the blood culture was performed ,and the results were observed and compared .RESULTS The serum PCT was tested positive in 67 cases of the observation group for the first‐time blood collection and in 8 cases of the control group （χ2 =43 .02 ,P〈0 .01） .The blood culture was positive in 12 cases of the observation group and in 1 case of the control group （χ2 =6 .05 ,P〈0 .05） .The serum PCT was tested positive in 61 （50 .8% ） patients of the observation group at 12 hours after the fever and in 68 （56 .7% ） patients of the observation group at 24 hours after the fever ;the blood culture was positive in 16 （13 .3% ） patients of the ob‐servation at 12 hours after the fever and in 31 （25 .8% ） patients of the observation group at 24 hours after fever , and there was significant difference （P〈0 .01） .The serum PCT was tested positive in 71 （59 .1% ） patients at 48 hours after fever ,while the blood culture was positive in 68 （56 .6% ） patients .CONCLUSION The detection of se‐rum PCT combined with blood culture has certain value in diagnosis of bloodstream infections ,and it is worthy to be promoted in the hospital .