替硝唑联合克林霉素治疗细菌性阴道炎临床疗效分析

Clinical efficacy of tinidazole combined with clindamycin in treatment of bacterial vaginosis

目的观察并分析替硝唑联合克林霉素治疗细菌性阴道炎的临床疗效,为临床治疗细菌性阴道炎提供参考依据。方法调查2014年1月-2015年2月医院收治的120例细菌性阴道炎患者临床资料,将其随机分为治疗组和对照组,每组各60例,对照组给予口服替硝唑治疗,治疗组在上述治疗基础上加用克林霉素磷酸酯阴道凝胶治疗;治疗1周后,比较两组患者临床疗效,与用药相关的不良反应及停药6个月后随访复发率。结果患者治疗后总有效率治疗组为91.67%、对照组为71.67%,两组相比差异有统计学意义(P<0.05);与治疗前比较,两组乳杆菌属检出率均较高,两组间比较差异无统计学意义;与治疗前比较,两组致病菌检出率均显著降低,治疗组降低幅度显著高于对照组,差异有统计学意义(P<0.05);治疗后,与对照组比较,治疗组患者恶心、口苦、乏力等不良反应发生率差异均无统计学意义;停药6个月后随访患者复发率治疗组为3.34%、对照组为15.00%,治疗组患者复发率明显低于对照组,差异有统计学意义(P<0.05)。结论对细菌性阴道炎患者采用替硝唑联合克林霉素治疗,能够显著提高临床疗效、降低复发率,值得临床推广使用。

OBJECTIVE To observe the clinical efficacy of tinidazole combined with clindamycin in treatment of bac‐terial vaginosis so as to provide guidance for clinical treatment of bacterial vaginosis .METHODS The clinical data of 120 patients with bacterial vaginosis who were treated in the hospital from Jan 2014 to Dec 2015 were investiga‐ted ,then the participants were randomly divided into the treatment group and the control group ,with 60 cases in each .The control group was treated with oral administration of tinidazole ,while the treatment group was given additional clindamycin phosphate vaginal gel on the basis of the above treatment .The clinical efficacies and medi‐cation‐related adverse reactions were compared between the two groups after the treatment for 1 week ,and the re‐currence rates were observed after a 6‐month follow‐up .RESULTS The total effective rate of treatment was 91 .67% in the treatment group ,71 .67% in the control group ,and there was significant difference between the two groups （P〈0 .05） .The isolation rate of Lactobacillus was higher in the two groups after the treatment ,and there was no significant difference between the two groups .The isolation rate of pathogenic bacteria was remark‐ably reduced in the two groups after the treatment ,and the decreased magnitude of the treatment group signifi‐cantly was greater than that of the control group （P〈0 .05） .There was no significant difference in the incidence of the adverse reactions such as nausea ,bitter taste ,and fatigue between the treatment group and the control group .The follow‐up showed that the recurrence rate of the treatment group was 3 .34% after the withdrawl of antibiotics for 6 months ,significantly lower than 15 .00% of the control group （P〈0 .05） .CONCLUSION Tini‐dazole combined with clindamycin can significantly improve the clinical efficacy in the treatment of the patients with bacterial vaginosis and reduce the recurrence rate ,and it is worthy to be promoted in the hospital .