慢性阻塞性肺疾病骨骼肌能量代谢研究现状

A review on muscle energy metabolism of COPD

骨骼肌功能障碍作为慢性阻塞性肺疾病最常见的肺外效应之一,是其预后的重要独立因素。能量代谢异常是骨骼肌功能障碍的主要机制之一,本文从线粒体代谢、炎症因子、瘦素等方面对COPD骨骼肌能量代谢进行综述,为开展进一步研究提供依据。

As one of the most common extrapulmonary effects of COPD, skeletal muscle dysfunction is an important independent prognostic factor. The abnormal energy metabolism is one of the main mechanisms of skeletal muscle dysfunction. In this paper, perspective of the mitochondrial metabolism, inflammation factors and leptin, skeletal muscle energy metabolism of patients with COPD were reviewed, in order to provide the basis for further research.