莲子心对不稳定型心绞痛患者血清基质金属蛋白酶水平及生存质量的影响

The Effects of Plumula Nelumbinis on the Levels of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 and Life Quality in Patients with Unstable Angina

目的观察莲子心对不稳定型心绞痛(UAP)患者的血清基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶抑制因子-1(TIMP-1)水平和生存质量的影响。方法研究共计纳入UAP患者120例以及健康人30例(正常组),其中UAP患者随机分为两组各60例,两组均进行标准化基础治疗,其中治疗组加用莲子心颗粒剂,疗程3周。治疗前后检测血清MMP-9和TIMP-1水平变化;并采用西雅图心绞痛量表(SAQ)进行生活质量评价。结果与正常组相比,治疗前治疗组和对照组的血清MMP-9、TIMP-1水平均明显增高(P<0.001),但治疗组和对照组间差异无统计学意义(P>0.05)。治疗后,治疗组和对照组血清MMP-9及TIMP-1水平均明显下降(P<0.001);且治疗组血清MMP-9及TIMP-1水平均明显低于对照组(P<0.05或P<0.01)。治疗后,对照组和治疗组均可使SAQ评分升高(P<0.01),但是治疗后治疗组AS、AF、TS评分明显高于对照组(P<0.01)。结论莲子心可在标准治疗基础上,降低UAP患者患者血清MMP-9、TIMP-1水平,从而改善生存质量。

Objective： To observe the effects of Plumula nelumbinis on the levels of Matrix Metalloproteinase-9（MMP-9） and Tissue Inhibitor of Metalloproteinase-1（TIMP-1） and life quality in patients with unstable angina.Methods： 120 patients with unstable angina were randomly divided into the treatment group（n = 60） and the standard treatment group（the control group,n= 60）. A normal group of 30 healthy persons was additionally set up.The treatment group and the control group both received standard treatment,and the treatment group was added Plumula nelumbinis. The course of treatment lasted for 3 weeks. Changes in levels of MMP-9 and TIMP-1 were measured and Seatle Angina Questionnaire（SAQ） was adopted in studying life quality before and after treatment.Results： Before treatment,compared with the normal group,the average levels of MMP-9 and TIMP-1in the other two groups increased obviously（P〈0.001）,but there was no significant difference in the average levels of MMP-9and TIMP-1 in the control group and the treatment group（P〉0.05）. After treatment,there was an obvious drop in the average levels of MMP-9 and TIMP-1in the control group and the treatment group（P〈0.001）,and that of the treatment group was lower than that of the control group（P〈0.01 or P〈0.05）. There was no significant difference in the scores of SAQ（PL,AS,AF,TS,DP） between two group before treatment（P〉0.05）. After treatment,the scores of SAQ（PL,AS,AF,TS,DP） were higher than before treatment（P〈0.01）,but the scores of SAQ（AS,AF,TS） in the treat group were obviously higher than that of the control groups（P〈0.01）. Conclusion： Plumula nelumbinis can decline the levels of MMP-9 and TIMP-1 and raise scores of SAQ in patients with unstable angina on the basis of standard treatment,so as to improve the quality of life.