艾灸对原发性肾病综合征大剂量激素治疗阶段患者细胞免疫调节的影响

Study of cellular immunoregulation effect of moxibustion on primary nephritic syndrome in patients during high-dose corticosteroids phase

目的观察艾灸对原发性肾病综合征大剂量激素治疗阶段患者细胞免疫调节的影响。方法将原发性肾病综合征大剂量激素治疗阶段的患者90例随机分2组。治疗组45例予艾灸+糖皮质激素+基础治疗,对照组45例予糖皮质激素+基础治疗,疗程均为12周。观察2组治疗前后T细胞亚群(CD3、CD4、CD4/CD8)及患者感染发生率等。结果治疗组治疗后CD3、CD4及CD4/CD8均增高(P<0.01),且高于对照组治疗后(P<0.01);治疗组感染率低于对照组(P<0.01)。结论艾灸可调节原发性肾病综合征大剂量激素治疗阶段患者的细胞免疫功能,减少感染发生率。

Objective To observe the cellular immunoregulation effect of moxibustion on primary nephritic syndrome （PNS） in patients during high - dose corticosteroids phase. Methods 90 PNS patients during high - dose corticosteroids phase were randomly divided into two groups. 45 patients in treatment group were treated by moxibustion, glucocorticoid and basic treatment. 45 patients in control group were treated by glucocorticoid and basic treatment. The course was 12 weeks in two groups. The T- cell subclasses （CD3, CD4, CD4/CD8） and the incidence rate of infection before and after treatment were observed. Results The levels of CD3, CD4 and CD4/CD8 after treatment were increased in treatment group （P 〈 0.01 ）, and the increase in treatment group was superior to that in control group （ P 〈 0.01 ）. The incidence rate of infection in treatment group was lower than that in control group （ P 〈 0.01 ）. Conclusion Moxibustion can regulate the cellular immune function on PNS in patients during high - dose corticosteroids phase, decrease the incidence rate of infection.