摘要
来源于早期外胚间充质组织头部的神经嵴细胞迁移衍生出牙髓间充质干细胞,随后这些细胞产生牙髓细胞和成牙本质细胞。神经胶质细胞是另外一个神经嵴细胞衍生迁移而形成的细胞系。神经胶质细胞有广泛的分化发育潜能,研究发现神经胶质细胞可以分化为神经细胞和牙髓间充质干细胞,并且神经胶质细胞的不同分化发育阶段间可以互相转变。通常认为,大多数组织中的间充质干细胞来源于血管周细胞,但有研究发现相当一部分牙髓间充质干细胞来源于外周神经相关的神经胶质。本文通过对神经嵴细胞、牙髓间充质干细胞和神经胶质细胞的分化发育以及神经胶质细胞的衍生细胞的概述,介绍牙髓再生领域一种新的更有前景的牙髓间充质干细胞来源。
Dental mesenchymal stem cells derive from neural crest cells after migrating from the early head of ectomesenchymal tissue. They later give rise to pulp cells and odontoblasts. Glial cells are another cell lineage neural crest cells derived. With surprisingly broad developmental potential,glial cells can differentiate to many cell types such as neurons and dental mesenchymal stem cells. Besides,glial cells from different developmental stages are interchangeable. Current consensus holds that perivascular cells form mesenchymal stem cells in most tissues. However,recent researches show that a few dental mesenchymal stem cells are derived from peripheral nerve？associated glia. This review aims to introduce a new and prospective origin of dental mesenchymal stem cells for dentistry regeneration by summaring the development of neural crest cells,dental mesenchymal stem cells and glial cells as well as glial cell derived cells.
出处
《中华口腔医学研究杂志（电子版）》
CAS
2015年第5期56-60,共5页
Chinese Journal of Stomatological Research(Electronic Edition)
基金
国家自然科学基金(81170928)
北京大学临床医院合作专项(2013-4-01)
