留置针联合普瑞巴林治疗带状疱疹后遗神经痛

Therapeutic observation of indwelling needle combined with pregabalin for postherpetic neuralgia

目的比较留置针联合普瑞巴林治疗带状疱疹后遗神经痛(post-herpetic neuralgia,PHN)的疗效。方法选取56例PHN患者,随机分为两组,各28例,均常规予以营养神经药物。对照组予以普瑞巴林300mg/d治疗,治疗组在口服普瑞巴林300mg/d基础上联合留置针治疗,4周为一疗程。用视觉模拟评分(visual analogue scale,VAS)评估患者疼痛程度,比较两组患者在治疗前、治疗2周、治疗4周及停止治疗后4周的疼痛程度,比较24小时持续睡眠时间,并观察不良反应。结果两组治疗后各时期的VAS值较治疗前均下降,差异有统计学意义(P<0.05),且各时期治疗组的VAS值较对照组低,差异有统计学意义(P<0.05);两组治疗后各时期的24小时持续睡眠时间均较治疗前增加,差异有统计学意义(P<0.05)。所有患者在治疗期间均未见严重不良反应。结论留置针联合普瑞巴林治疗PHN可明显缓解患者疼痛。

Objective To investigate the efficacy of indwelling needle combined with pregabalin for post-herpetic neuralgia（PHN）.Method Fifty-six patients with PHN were randomly divided into two groups and each group contained 28 cases. Both were routinely treated with neurotrophic drugs. The patients in control group were given pregabalin 300mg/d and those in the treatment group received pregabalin 300mg/d combined with indwelling needle. Four weeks was considered as a period of treatment. We compared the levels of pain measured by visual analogue scale （VAS） and 24-hour sleep duration before the treatment,two weeks after treatment,four weeks after treatment and four weeks after cessation of treatment. Result The value of VAS in the two groups was decreased after treatment and the difference was statistically significant（P 〈 0.05）and was lower in the treatment group than the control group with statistical significance（P 〈 0.05）.The 24 hours sleep duration in the two groups was increased after treatment and the difference was statistically significant（P 〈 0.05）. There were no serious adverse effects in all patients. Conclusion Indwelling needle combined with pregabalin can rapidly alleviate pain. It is effective for the treatment of PHN.