归仙壮阳口服液毒性实验研究

Toxicity Test on Guixianzhuangyang Oral Liquid

目的 :探讨归仙壮阳口服液对大鼠产生的急性毒性反应和长期毒性反应。方法 :采用 2 5 ml/ kg饲喂小鼠和 2 0 ml/kg饲喂大鼠 1周做急性毒性实验 ,观察动物的一般状况 ;采用低、中、高剂量组和对照组做长期毒性实验 (3个月 ) ,观察大鼠的生长发育、血液常规和血液生化指标。结果 :急性毒性实验显示受试动物无异常反应 ,无一死亡。长期毒性实验显示动物进食量、生长发育正常 ,血液学和血液生化指标测定均在正常值范围内 ,重要脏器指数和病理学检查无异常 ,试验组与对照组比较无显著差异。结论 :归仙壮阳口服液对大鼠无毒性。

Objective:To investigate the acute toxicity reaction and long term toxicity reaction of rats when given Guixianzhuangyang Oral Liquid.Methods:In acute toxicity test, mice and rats were administrated respectively with Guixianzhuangyang Oral Liquid in one dose for one week. Mice were given at doses of 25 ml/kg and rats were treated with at doses of 20 ml/kg. Then general conditions of animals were observed. In long term toxicity test, low, middle, high dosage groups and control group were treated with Guixianzhuangyang Oral Liquid for three months. Then growing development of rats, blood routine examination, blood biochemical criterion were observed.Results:The results of acute toxicity test showed the animals had no abnormal reaction and none was dead. In long term toxicity test, the results showed that the diet, growing development, blood routine examination, blood biochemical criterion and major organ index of rats were normal. Major organs were not found abnormity in pathological test. Comparing with control group, the difference was not distinct.Conclusion:Guixianzhuangyang Oral Liquid was not toxical to rats.