女性早发冠心病患者睡眠状况的调查及分析

The Analysis of Sleep Quality with Premature Coronary Artery Disease in Women

目的通过对女性早发冠心病患者睡眠状况的调查分析探讨睡眠质量与疾病的关系。方法 2014年1月至2015年7月共271名年龄小于65岁的女性患者住院治疗,其中经冠脉造影证实冠心病患者(病例组)208例,冠脉造影正常患者(对照组)63例,使用匹兹堡睡眠质量指数量表(PSQI)对患者的睡眠质量进行评价,睡眠障碍定义为PSQI>5,应用logistic回归分析睡眠质量与女性早发冠心病危险分层的关系。结果病例组PSQI总分6.33±3.44,对照组PSQI总分7.02±3.85,两组相比无显著性差异,在病例组中,排除混杂因素的影响,与睡眠正常者相比较,睡眠障碍者出现急性冠脉综合征(ACS)的可能性更大(OR:2.52;95%CI:1.25,5.05)。结论在女性早发冠心病患者中,睡眠质量与疾病危险分层有关,睡眠障碍者出现ACS的可能性更大,睡眠障碍可能是疾病的重要危险因素。

Objective To investigate the sleep quality of patients with premature coronary artery disease（p CAD） and to explore the association between sleep quality and p CAD in women. Methods A total of 271 women（65 yrs） undergoing coronary angiography in Fuwai Hospital from Jan. 2014 to Jul. 2015 were invited to participate this study（208 cases and 63 controls）. Sleep quality was measured with Pittsburg Sleep Quality Index（PSQI）. Poor sleep quality was defined as PSQI〉5. Logistic regression model was used to assess association between sleep quality and acute coronary syndrome（ACS）. Results The PSQI score was 6.33±3.44 in case and 7.02±3.85 in control. In women with p CAD, compared with patients with PSQI〈=5, the patients with poor sleep quality（PSQI〉5） had a higher risk of ACS（odds ratios [ORs]： 2.52, 95% confidence interval [CI]：1.25, 5.05）. Conclusions There was a positive association between poor sleep quality with ACS in women with p CAD. This result suggest that poor sleep quality may be an important modifiable p CAD risk factor in women.