高血压病患者Hcy和VitD检测的临床意义

The Clinical Significance of Hypertension in Patients with HCY and VITD Detection

目的观察高血压病患者同型半胱氨酸(Hcy)和维生素D(Vit D)变化,探讨Hcy和Vit D与高血压病有无内在联系;对高血压病合并症冠心病或2型糖尿病有无潜在影响。方法入选我院心内科高血压患者227例;同期门诊正常体检者128例为对照组;采用循环酶法测定Hcy水平,酶联免疫法测定Vit D水平。结果(1)高血压病患者Hcy升高者达80.17%;Vit D降低者达88.99%;高血压病患者Hcy水平较对照组明显升高,差异有统计学意义(P<0.05);Vit D水平较对照组明显降低,差异有统计学意义(P<0.05)。(2)高血压病合并冠心病者,较不合并冠心病者:Hcy水平显著升高,差异有统计学意义(P<0.05);Vit D水平显著升高,差异有统计学意义(P<0.01)。(3)高血压病合并2型糖尿病者,较不合并2型糖尿病者:Hcy水平降低,但差异无统计学意义(P>0.05);Vit D水平明显降低,差异有统计学意义(P=0.01)。(4)高血压病患者血浆Hcy与Vit D呈负相关。结论高Hcy(HHcy)和低Vit D水平在高血压病发生、发展过程中有重要作用,HHcy和高Vit D水平是冠心病的危险因素;低Vit D水平是2型糖尿病的危险因素。

Objective To analyze the relationship between Homocystein（Hcy）, Vitamin D（Vit D） and hypertension, as well as whether Hcy and Vit D have effect on hypertension complicated with coronary heart or type 2 diabetes. Methods 227 patients with hypertension in our hospital department of cardiology as experimental group and 128 outpatients with normal physical examination as control group. The concentrations of plasma Hcy and Vit D were determined by using circulating enzymatic method and ELISA. Results（1） The proportion of patients with hypertension and higher levels of Hcy were 80.17%, the proportion of patients with hypertension and lower levers of Vit D were 88.99%. The levels of Hcy in patients with hypertension were signif icantly higher than the control group（p〈0.05）.（2）Compared with hypertension complicated without coronary heart disease, patients with hypertension complicated with coronary heart disease have signif icantly higher levels of Hcy（ p〈0.05） and Vit D（ p〈0.01）.（3）Compared with hy per tension complicated without t y pe 2 diabetes, patients with hypertension complicated with type 2 diabetes have significantly lower levels of Vit D（p=0.01）, they also have lower levels of Hcy, but there was no significant difference between two groups（p〈0.05）.（4）There was a negative correlation between Hcy and Vit D in patients with hypertension（r=-0.133, p=0.045）. Conclusion High level of Hcy and low level of Vit D play important pathophysiologic role in hypertension. High level of Hcy and low level of Vit D are coronary heart disease＇s risk factors; Low level of Vit D is type 2 diabetes＇ risk factors.