尿酸水平对心肌梗死发病及其预后影响研究现状

Review on the Influence of Uric Acid on the Onset and Prognosis of Myocardial Infarction

急性心肌梗死具有较高的并发症发生率和死亡率,严重威胁人类健康。研究表明除传统危险因素外,血清中尿酸水平对急性心肌梗死的发生和心肌梗死预后具有预测作用。其可能机制包括尿酸盐对血管壁的损伤作用、氧化应激和过度耗氧等。针对尿酸水平的干预治疗可能是减少急性心肌梗死发生、乃至改善急性心肌梗死预后的治疗靶点。

Objective Acute myocardial infarction is a life-threatening disorder due to high morbidity and mortality. It is demonstrated that serum uric acid, beyond other conventional cardiovascular risk factors, is predictive of the onset and prognosis of acute myocardial infarction. This result may be underlain by direct injury of urate to the vessel wall, oxidative stress and over consumption of oxygen in ischemic cardiomyocytes. Medications interfering uric acid may be important therapeutic approaches against acute myocardial infarction and its following adverse events.