低剂量HA方案治疗难治性、复发性AA-PNH综合症1例并文献复习

A case of refractory and recurrent AA-PNH syndrome treated with low-dose HA regimen and literature review

再生障碍性贫血（AA）及阵发性睡眠性血红蛋白尿（PNH）均是常见疾病,二者经常演变为AAPNH综合症。对于难治性、复发性AA-PNH患者,常规治疗效果甚差。我院采用低剂量HA方案治疗1例年轻女性患者,取得了比较满意的效果,现报告如下,并综合相关文献进行分析讨论。1病例资料患者,女,22岁,因头晕、乏力8个月余,于2010年9月14日入院。体检：重度贫血貌,全身皮肤黏膜苍白,巩膜无黄染,浅表淋巴结未肿大。

AA and PNH are common diseases,both of which often evolve into AA-PNH syndrome.For patients with refractory and recurrent AA-PNH syndrome,the curative effect of conventional therapy is very poor.We treated a young female patient with low-dose HA regimen and achieved satisfactory results,now it is reported as follows and related literature are discussed.