长叶缬草化学成分的研究

Chemical constituents from whole plants of Valeriana hardwickii

对长叶缬草的化学成分进行研究,通过硅胶、Sephadex LH-20柱色谱,制备TLC和反相制备HPLC分离技术,从长叶缬草全草的乙醇提取物中分离得到13个化合物,经MS和NMR等波谱技术鉴定了它们的结构,其中包括11个黄酮类化合物：6,8-二甲基芹菜素（1）,6-甲基芹菜素（2）,5-羟基-7,4＇-二甲氧基黄酮（3）,芫花素（4）,金合欢素（5）,芹菜素（6）,槲皮素（7）,麦黄酮（8）,杜鹃素（9）,异野樱素（10）,5,3＇,4＇-三羟基-7-甲氧基二氢黄酮（11）;2个单萜类化合物：（-）-bornyl ferulate（12）和（-）-bornyl caffeate（13）。所有化合物均为首次从该植物分离得到,化合物1,9~13为首次该从属植物中分离得到。

Chemical investigation of the whole plants of Valeriana hardwickii has led to the isolation of 11 flavones and 2 monoterpenoids by using various chromatographic techniques including column chromatography on silica gel and Sephadex LH-20,preparative TLC,and preparative HPLC. Their structures were identified by spectroscopic data analysis as syzalterin（ 1）,6-methylapigenin（ 2）,5-hydroxy-7,4＇-dimethoxyflavone（ 3）,genkwanin（ 4）,acacetin（ 5）,apigenin（ 6）,quercetin（ 7）,tricin（ 8）,（-）-farrerol（ 9）,isosakuranetin（ 10）,5,3＇,4＇-trihydroxy-7-methoxyflavanone（ 11）,（-）-bornyl ferulate（ 12）,and（-）-bornyl caffeate（ 13）. All compounds were isolated from this plant for the first time,while compounds 1,9-13 were obtained from this genus for the first time.