短孔道SBA-15固载奎宁催化不对称Michael加成反应

SHORT-MESOCHANNEL SBA-15 SUPPORTED QUININE FOR ASYMMETRIC MICHAEL ADDITION REACTIONS

合成了大小为400～500nm片状的短孔道SBA-15，并在其表面固载奎宁，制得一种有效的非均相有机催化剂，对其进行了XRD、FT—IR、电镜表征。以查尔酮类化合物与丙二腈的不对称Michael加成反应为模型考察了非均相催化剂催化活性，结果表明：以短孔道SBA-15为载体的催化剂和以常规SBA-15为载体的催化剂对查耳酮、4-甲氧基查尔酮、4-氟查尔酮为底物的反应产物收率对比为56％VS50％，58％VS45％，60％VS54％，对映选择性对比为56％VS36％，37％VS26％，41％VS34％。与SBA-15为载体固载奎宁制备催化剂相比，短孔道SBA-15固载的奎宁催化剂表现出了高于前者的催化活性和对映选择性。

Short-mesochannel SBA-15 with the size of 400 -500 nm was synthesized and immobilized quinine to build an effective heterogeneous chiral organic catalyst. It was characterized by XRD, FT- IR, SEM and TEM. The heterogeneous catalyst was evaluated for the asymmetric Michael addition of malononitrile to chalcones. The short-mesochannel SBA-15 supported catalyst compared with conventional SBA-15 to chalcone, 4-methoxy chalcone, 4-fluoro chalcone for the asymmetric Michael addition reaction, experimental results show that product yield were 56% VS 50%, 58% VS 45% and 60% VS 54%, theenantioselectivities were 56% VS 36%, 37% VS 26% and 41% VS 34%. For most substrate, higher catalytic activities and enantioselectivities were achieved than the conventional catalyst.