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血小板高反应性的指南、专家共识解读 被引量：10

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摘要 急性冠状动脉事件的发生发展中,血小板的黏附、活化、聚集起着关键性作用,因此,抗血小板治疗已成为防治血栓形成、减少临床不良事件发生的重要基石.目前,阿司匹林加用氯吡格雷仍然是冠心病介入治疗（percutaneous coronary intervention,PCI）和急性冠状动脉综合征（ acute coronary syndrome,ACS） 的标准抗血小板治疗方案[1] .其安全性和疗效在一系列临床试验中得到证实,得到ESC、AHA、中国等众多指南推荐,具有广泛的适应证,包括择期冠状动脉介入术、非ST段抬高性心肌梗死（non-ST-elevation myocardial infarction,NSTEMI）、ST 段抬高性心肌梗死（ST segment elevationacute myocardial infarction,STEMI） 以及二级预防等.
作者 田新利 李俊峡
机构地区 北京军区总医院心血管疾病研究所
出处 《中国医刊》 CAS 2015年第11期25-28,共4页 Chinese Journal of Medicine
关键词 抗血小板治疗 非ST段抬高性心肌梗死 高反应性 指南 急性冠状动脉综合征 急性冠状动脉事件 冠心病介入治疗 冠状动脉介入术
分类号 R331.1 [医药卫生—人体生理学]
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参考文献16

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同被引文献88

  • 1陈民利,寿旗扬,潘永明,张建兵,桑睿,管敏文,吴碧元.冠心宁片对气滞血瘀大鼠抗血小板聚集和保护血管内皮作用[J].中国临床药理学与治疗学,2005,10(5):586-589. 被引量：35
  • 2柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304. 被引量：2146
  • 3中华医学会第四次脑血管病学术会议.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29:379.
  • 4Han SW, Kim SH, Lee JY, et al. A new subtype classification of ischemic stroke based on treatment and etiologic mechanism[J]. Eur Neurol, 2007, 57(2):96-102.
  • 5Bliden KP, Tantry US, Zaman K, et al. High platelet reactivity is a risk factor for post-discharge ischemic complications following elective coronary stenting[J]. J Am Coil Cardiol, 2005(47):33A.
  • 6Prahbakaran S, Well KR, Lee VH, et al. Prevalence and risk factors for aspirin and elopidogrel resistance in cerebrovascular stenting[J]. AJNR Am J Neuroradiol, 2008, 29(2):281-285.
  • 7Shim CY, Yoon S J, Park S, et al. The clopidogrel resistance can be attenuated with triple antiplatelet therapy in patients undergoing drug-eluting stents implantation[J]. Int J Cardiol, 2009, 134(3):351- 355.
  • 8Matetzky S, Shenkman B, Guetta V, et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic eventsin patients with acute myocardial infarction[J]. Circulation, 2004, 109(25):3171-3175.
  • 9Kono Y, Yamada S, Kamisaka K, et al. Recurrence risk after noncardioembolic mild isehemic stroke in a Japanese population[J]. Cerebrovasc Dis, 2011, 31(4):365-372.
  • 10Juurlink DN, Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel[J]. CMAJ, 2009, 180(7):713-718.

引证文献10

二级引证文献58

中国医刊
2015年 第11期

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