消化性溃疡合并上消化道出血的相关危险因素分析

Analysis of related risk factors for the upper-gastrointestinal bleeding in peptic ulcer disease

[目的]分析消化性溃疡合并上消化道出血的相关危险因素。[方法]将324例消化性溃疡患者,按是否合并上消化道出血分为观察组(75例)、对照组(249例),对2组临床资料中一般情况、生活习惯、饮食习惯和用药情况等进行回顾性分析。[结果]观察组性别、年龄、病程、职业以及有非甾体类抗炎药用药史和Hp感染史患者比率均高于对照组,差异有统计学意义(P<0.05),而2组婚姻、家族史比较,差异无统计学意义(P>0.05)。观察组长期吸烟、嗜酒、喜食辛辣刺激食物、生活无规律患者比率均高于对照组,差异有统计学意义(P<0.05)。观察组溃疡直径≥20mm、溃疡处于活动期、抑郁、失眠患者比率均高于对照组,差异有统计学意义(P<0.05),而2组溃疡部位比较,差异无统计学意义(P>0.05)。[结论]服用非甾体类抗炎药、有Hp感染及不良的生活习惯是消化性溃疡合并上消化道出血的危险因素。

Objective]To investigate the related risk factors for the upper‐gastrointestinal bleeding （UGIB）in peptic ulcer disease（PU）.[Methods]A retrospective analysis was performed for 324 cases of PU patients in our hospital during 2010 January -2014 January ,in which 75 patients complicated with UGIB were considered as observation group（OG） ,and 249 patients without UGIB complication were considered as control group（CG）.The clinical data of the general condition ,living habits ,diet and medication were competitively analyzed. [Results ] T he ratio of gender ,age ,disease duration ,occupation ,the history of NSAIDS intake and Hp positive rate in OG were significantly higher than those in CG（P〈0.05） .Howev‐er ,there was no significant difference in the family history and marital status between the two groups（P〉0.05）.Meanwhile ,the ratio of long‐term smoking ,drinking ,eating spicy food in OG were significantly higher than those in CG（P〈0.05）.Furthermore ,the ratio of ulcer diameter larger than 20 mm ,ulcer in ac‐tive phase were higher in OG than those in CG（P〈0.05）;while ,the ulcer site comparison had no signifi‐cant difference between groups（P〉0.05）.In an addition ,the ratio of depression ,insomnia and regular life were higher in OG than those in CG（P〈0.05）.[Conclusion]NSAIDs intake ,H p infection and unhealthy living habit are the risk factors for UGIB in PU.