慢性乙型肝炎患者肝组织学改变的影响因素分析

Evaluation of the influence factors associated with liver histology changes in patients with chronic hepatitis B infection

[目的]探讨慢性乙型病毒性肝炎(CHB)患者肝组织学改变的相关影响因素。[方法]选取CHB患者55例,根据肝炎病情程度分为G1S0-1组与G2-4S2-4组,分析2组患者性别、年龄、血清丙氨酸转氨酶(ALT)、乙肝血清标志物(HBeAg)及乙肝病毒DNA(HBV DNA)水平与肝脏组织学改变的关系。[结果]肝脏的炎症活动度和纤维化程度随年龄的增大、血清ALT及HBV DNA水平的增高而加重,多因素分析显示HBV DNA水平是慢性乙肝患者肝组织学改变的独立影响因素。[结论]慢性乙肝患者肝组织病变程度与患者年龄、血清ALT及HBV DNA水平有相关性,其中HBV DNA水平是慢性乙型肝炎患者肝组织病变的独立影响因素。

[Objective]To study the factors associated with liver histological changes in patients with chronic hepatitis B virus（HBV）infection.[Methods]Total patients with chronic HBV infection collected from January to December 2013 were included in this study.All the patients were randomly divided into G1S0‐1 group（32 cases）and G2‐4S2‐4 group（23 cases）according to the degree of hepatitis.The correlations between liver tissue pathologic and sex ,ages ,ALT ,HBeAg status and HBV DNA serum level were ana‐lyzed.[Results]The activity of liver inflammation and fibrosis degree were positively associated with ages , ALT and HBV DNA serum level.The multiple‐factor analysis suggested that HBV DNA serum level was an independent risk factor for liver histological changes.[Conclusion]Liver tissue pathologic abnormality is associated with ages ,ALT and HBV DNA serum level.HBV DNA serum level is an independent risk fac‐tor.