Skp2表达对食管癌术后复发及预后的影响

Effects of Skp2 overexpression on postoperative recurrence and prognosis in patients with esophageal cancer

目的研究Skp2表达对食管癌术后复发及预后的影响。方法对74例食管癌手术切除患者的病理标本进行Skp2免疫组化染色,并收集术后完整临床资料及随访资料,进行统计学分析。应用Cox比例风险模型对可能影响食管癌预后的因素进行分析,用Log-rank检验分析Skp2对总生存期(OS)、无肿瘤生存期(DFS)、局部无复发生存期(LRFS)及远处无复发生存期(DMFS)的影响。结果食管癌组织中Skp2的阳性表达率为47.3%。Skp2表达阴性患者的3年及5年生存率显著高于Skp2表达阳性患者,差异有统计学意义(P<0.01)。在食管癌组织中Skp2的表达与肿瘤的大小、淋巴结转移、浸润深度、TNM分期有关(P均<0.01)。Skp2高表达食管癌患者术后OS、DSF、DMSF及LRFS显著低于Skp2低表达患者(P<0.05)。Cox多因素回归分析表明,TNM分期、肿瘤浸润深度、有无淋巴结转移、Skp2表达是食管癌患者生存的独立预测因素。结论 Skp2过表达是食管癌术后预后不良的重要因素。

Objective To study the effects of Skp2 overexpression on the postoperative recurrence and prognosis of esophageal cancer. Methods The pathological specimens of 74 patients with surgical resection of esophageal cancer were used for Skp2 immunohistochemical staining. In addition,complete postoperative clinical information and follow-up data were collected for statistical analysis. The parameters that might influence the prognosis results of esophageal cancer were analyzed using the Cox proportional hazards model. The effects of Skp2 on overall survival（ OS）,disease-free survival（ DFS）,local recurrence-free survival（ LRFS）,and distant metastasis-free survival（ DMFS） were analyzed using the Log-rank test. Results The positive Skp2 expression rate in esophageal cancer tissues was 47. 3 %. The 3-year and 5-year survival rate of the patients with negative Skp2 expression were significantly higher than those in patients with positive Skp2 expression. Skp2 expression was associated with lymph node metastasis,infiltration depth,and TNM staging of esophageal cancer（ P〈0. 01）. The results of the multivariate Cox regression analysis showed that TNM staging, tumor infiltration depth, lymph node metastasis, and Skp2 expression were independent predictors for the survival of esophageal cancer patients. The postoperative OS,DSF,DMSF,and LRFS rates of the patients with high levels of Skp2 expression were significantly worse than those with low levels of Skp2 expression. Conclusions Skp2 overexpression is an important factor of a poor postoperative prognosis of esophageal cancer.