胃食管反流病治疗进展

Recent progress in treatment of gastroesophageal reflux disease

胃食管反流病(GERD)一直以来以抑制胃酸分泌尤其是质子泵抑制剂的使用作为主要手段,但部分患者对其反应不佳或存在长期服药引起并发症的风险。目前基于恢复食管下括约肌功能的抗反流治疗得到了广泛重视和积极尝试,创立了手术、经口咽胃底折叠术(TF)、磁性括约肌扩张(MSA)、Stretta、食管下括约肌(LES)电刺激等一批新的治疗方式,可能成为GERD治疗的新方向,但其可行性及安全性评估尚未形成统一意见。

The inhibiting of gastric acid secretion, especially by the dosing of proton pump inhibitor is always the mainstay of treatment for Gastroesophageal reflux disease（GERD）, however, some of the patients have poor responses or the risk of causing complications after a long-term dose. Currently, the anti-reflux treatment which is based on the functional restoration of the lower esophageal sphincter has been attended widely and attempted actively. A batch of new treatment modalities such as surgical operation, TF, MSA, Stretta and LES electrical stimulation have been founded, which may be a new therapeutic target for GERD, but their feasibility and safety evaluation have not yet reached a consensus.