期刊文献+

男性和女性晚发型强直性脊柱炎73例临床特点分析

原文传递
导出
摘要 目的探讨不同性别晚发型强直性脊柱炎(LAS)的临床特点,提高对本病的诊断水平。方法回顾性分析73例明确诊断为LAs住院患者的临床表现、实验室及影像学结果,分析男性和女性LAS的临床特点。73例LAS患者中男43例(男性组),女30例(女性组)。女性组人类白细胞抗原(HLA)-B27阳性20例(66.7%,20/30),男性组HLA-B27阳性38例(88.4%,38/43)。结果女性组临床症状较轻,外周关节受累明显多于男性组,两组比较差异有统计学意义(P〈0.05)。男性组35例(81.4%,35/43)出现肺部受累,女性组19例(63.3%,19/30)出现肺部受累,两组比较差异有统计学意义(P〈0.05)。女性组红细胞沉降率(ESR)为(59.5±35.7)mm/1h、C反应蛋白(CRP)为(18.7±15.0)mg/L,男性组ESR为(47.0±42.7)mm/1h、CRP为(16.3±15.4)mg/L,两组比较差异有统计学意义(P〈0.05)。Bath强直性脊柱炎疾病活动指数(BASDAI)及Bath强直性脊柱炎功能指数(BASFI)男性组分别为4.4±3.5、54.8±10.2,女性组分别为3.8±2.3、51.4±8.7,两组比较差异有统计学意义(P〈0.05)。男性组骶髂关节炎症Ⅳ级15例(34.9%),女性组3例(10.0%),两组比较差异有统计学意义(P〈0.05)。结论LAS临床不少见,男性和女性LAS临床特点存在差异。
作者 严淑 陆亚华
出处 《中国医师进修杂志》 2015年第11期837-839,共3页 Chinese Journal of Postgraduates of Medicine
  • 相关文献

参考文献9

  • 1van der Horst-Bruinsma IE, Zack DJ, Szumski A, et al. Female patients with ankylosing spondylitis: analysis of the impact of gender across treatment studies [J]. Ann Rheum Dis,2013, 72 (7) : 1221-1224.
  • 2张洁,黄烽.晚发型强直性脊柱炎的临床分析[J].中华全科医师杂志,2007,6(5):305-306. 被引量:5
  • 3杨明灿,魏秋静,祁军,李秋霞,廖泽涛,林智明,张艳丽,吕青,胡载颖,古洁若.晚发型强直性脊柱炎34例临床特点分析[J].中华老年多器官疾病杂志,2012,11(12):897-900. 被引量:2
  • 4Chen HA, Chen CH, Liao HT,et al. Clinical, functional, and radiographic differences among juvenile-onset, adult-onset, and late-onset ankylosing spondylitis [J 1. J Rheumatol, 2012, 39(5 ) : 1013-1018.
  • 5Montilla C, Dd Pino-Montes J, Collantes-Estevez E, et al. Clinical features of late-onset ankylosing spondylitis: comparison with early-onset disease[J]. J Rheumatal, 2012, 39(5): 1008-1012.
  • 6Toussirot E. Late-onset ankylosing spoudyhtis and spondylarthfitis : an update on chnical manifestations, differential diagnosis and pharmacological therapies [ J ]. Drugs Aging, 2010, 27 (7) : 523 - 531.
  • 7Feldtkeller E, Khan MA, van der Heiide D,et al.Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis [ J 1. Rheumatol Int, 2003,23 (2) : 61- 66.
  • 8Ahin R, Ozdolap S, Savranlar A, et al. Comparison of early and late pleuropulmonary findings of ankylosing spondylitis by high-resolution computed tomography and effects on patients' daily life[ J ]. Clin Rheumatol, 2005,24( 1 ) :22-28.
  • 9方玲,樊晓海,叶夏云,钟建庭,许瑞元.93例女性强直性脊柱炎的诊断特点[J].军医进修学院学报,2010,31(5):418-419. 被引量:6

二级参考文献29

  • 1包军,刘欢,徐沪济.女性晚发型强直性脊柱炎二例报告[J].第二军医大学学报,2005,26(4):375-375. 被引量:2
  • 2潘文友,刘焱,刘华.晚发强直性脊柱炎10例报告[J].实用老年医学,2005,19(3):168-168. 被引量:2
  • 3康春来,魏瑞华.晚发强直性脊柱炎临床特点与治疗[J].中国疗养医学,2006,15(1):31-32. 被引量:3
  • 4方玲,钟建庭.强直性脊柱炎的诊治现状[J].中国医师进修杂志,2006,29(7):69-71. 被引量:10
  • 5张洁,黄烽.晚发型强直性脊柱炎的临床分析[J].中华全科医师杂志,2007,6(5):305-306. 被引量:5
  • 6Gensler LS, Ward MM, Reveille JD, et al. Clinical, radiographic, and functional differences between juvenile-onset and adult-onset ankylosing spondylitis : results from the PSOAS cohort [ J ] . Ann Rheum Dis, 2008, 67 ( 2 ) : 233-237.
  • 7Ostensen M, Forger F, Nelson JL, et al. Pregnancy in patients with rheumatic disease : anti-inflammatory cytokines increase in pregnancy and decrease post partum [ J ] . Ann Rheum Dis, 2005, 64 : 839-844.
  • 8Caplanne D, Tubach F, Le Parc JM. Late onset spondylarthropathy: clinical and biological comparison with early onset patients. Ann Rheum Dis,1997,56 : 176-179.
  • 9Dubost JJ, Sauvezie B. Late onset peripheral spondyloarthropathy. J Rheumatol, 1989, 16: 1214-1217.
  • 10Olivieri I,Salvarani C,Cantini F,et al. Ankylosing spondylitis and undifferentiated spondyloarthropathies: a clinical review and description of a disease subset with older age at onset. Curt Opin Rheumato1,2001,13 :280-284.

共引文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部