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利多卡因防治烧伤后增生性瘢痕的实验研究和临床应用 被引量：1

Experimental study on the mechanism of lidocanine preventing and curing hypertrophic scar and clinical application
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摘要 目的探讨利多卡因在防治瘢痕中的作用。方法采取组织块进行增生性瘢痕成纤维细胞(HSFB)体外培养,另选50例膝关节深Ⅱ度烧伤患者分为治疗组(25例,29只)用利多卡因0.75%浓度喷洒创面,对照组(25例,28只)用溶媒喷洒创面。结果利多卡因对HSFB的生长、胶原合成及Ⅰ、Ⅲ型前胶原基因表达均呈浓度低赖性抑制,其中以0.75%浓度作用最为显著。临床中治疗组的膝关节外观异常发生率,关节活动度和关节功能评分均明显优于对照组(P均<0.05)。结论利多卡因可以通过减少Ⅰ、Ⅲ型前胶原基因表达等途径抑制瘢痕增生。 Objective To explore the effect of lidocaine preventing and treating hypertrophic scar.Methods Fibroblast of hypertrophic scar was cultured in vitor,with different concentration Lidocaine.50 patients with deep Ⅱ degree burn on knee joint were randomly divided into treatment group(TG) and control group(CG).The wounds of TG were applied.Results Lidocaine inhibited HSFB proliferation,collagen synthesis and gene expression by a close depended manner,especially treated with 0.75% lidocaine.Abnormal rate of knee joint external form,ROM,and joint function score in TG were superior to CG(P< 0.05).Conclusion By inhibiting Ⅰ,Ⅲ precollage gene expression,lidocaine can inhibit the formation of hypergtrophic scar
作者 李黎
机构地区 商丘市第一人民医院
出处 《中国临床康复》 CSCD 2002年第16期2378-2379,I002,共3页 Chinese Journal of Clinical Rehabilitation
关键词 烧伤 临床应用 利多卡因 瘢痕 成纤维细胞 胶原 lidocaine hypertrophic scar fibroblast collagen
分类号 R644 [医药卫生—外科学] R619.6 [医药卫生—外科学]
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中国临床康复
2002年 第16期

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