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血管紧张素受体脑啡肽酶抑制剂在心力衰竭中的研究进展 被引量：27

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摘要 心力衰竭(心衰)的传统治疗致力于神经体液系统过度激活,如肾素—血管紧张素—醛固酮系统(RAAS)在心衰的病理生理中扮演基础作用,然而基于传统的心衰治疗方案,心衰患者的死亡率仍很高,远期预后及生活质量差,新近出现的血管紧张素受体脑啡肽酶抑制剂(LCZ696)为心衰患者带来了新的希望,既阻断RAAS又增加利尿钠肽,脑啡肽酶抑制剂抑制脑啡肽酶降解钠尿肽,增加钠尿肽从而发挥促进血管舒张和尿钠排泄,抑制病理性生长,抑制RAAS和交感神经系统活性和增加副交感神经系统活性的作用。具有双重抑制作用的LCZ696开创了新的心衰的治疗方法。
作者 邱爽 杨波 平海芹 王慧 周三凤
机构地区 武汉大学人民医院心血管内科
出处 《中国循环杂志》 CSCD 北大核心 2015年第11期1131-1133,共3页 Chinese Circulation Journal
基金 湖北省基金重点项目(2014CFA061)
关键词 血管紧张素受体脑啡肽酶抑制剂 心力衰竭 研究进展
分类号 R541 [医药卫生—心血管疾病]
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参考文献30

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二级参考文献42

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共引文献56

同被引文献165

引证文献27

二级引证文献433

中国循环杂志
2015年 第11期

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