哮喘患儿呼出气一氧化氮浓度、肺功能及哮喘控制测试评分的相关性及其评估价值研究

Correlations among Fractional Exhaled Nitric Oxide Concentration,Lung Function and Asthma Control Test Score in Children with Asthma and Their Assessment Value

目的探讨哮喘患儿呼出气一氧化氮(Fe NO)浓度、肺功能、哮喘控制测试(ACT)评分的相关性及其评估价值。方法选取2013年12月—2014年12月在衡水市桃城区妇幼保健院小儿呼吸科门诊初治1个月后的哮喘患儿162例,检测患儿Fe NO浓度及肺功能,进行ACT评分,并分析FeNO浓度、肺功能及ACT评分间的相关性。结果 162例患儿中肺功能正常者105例(占64.81%),肺功能轻度减退者57例(占35.19%);FeNO正常者64例(占39.51%),偏高者62例(占38.27%),较高者36例(占22.22%)。Pearson相关性分析结果显示,ACT评分与FeNO浓度呈中度负相关(r=-0.668,P=0.000);ACT评分与第一秒用力呼气容积占预计值百分比(FEV1%)呈高度正相关(r=0.754,P=0.000);FEV1%与FeNO浓度呈中度负相关(r=-0.524,P=0.000)。结论哮喘患儿FeNO、肺功能及ACT评分间具有相关性,ACT评分可用以评估哮喘患儿疾病控制情况,肺功能和FeNO浓度可用以评估哮喘患儿气道炎症和疾病控制情况。

Objective To investigate the correlations among fractional exhaled nitric oxide（ Fe NO） concentration,lung function and Asthma Control Test（ ACT） score in children with asthma and their assessment value. Methods From December 2013 to December 2014 in the Department of Pediatric Respiratory Outpatient,Maternal and Child Care Service Center of Taocheng District,a total of 162 children with asthma that treated for one month were selected,Fe NO concentration and lung function were detected,ACT score was evaluated,and correlations among them were analyzed. Results Of the 162 children,105 cases＇ lung function were normal（ accounted for 64. 81%）,57 cases＇ lung function were mildly impaired（ accounted for35. 19%）; 64 cases＇ Fe NO concentration were normal（ accounted for 39. 51%）,62 cases＇ Fe NO concentration were mildly elevated（ accounted for 38. 27%）,36 cases＇ Fe NO concentration were obviously elevated（ accounted for 22. 22%）. Pearson correlation analysis showed that,ACT score was moderately negatively correlated with Fe NO concentration（ r =- 0. 668,P =0. 000）,ACT score was highly positively correlated with FEV1%（ r = 0. 754,P = 0. 000）,FEV1% was moderately negatively correlated with Fe NO concentration（ r =- 0. 524, P = 0. 000）. Conclusion There are correlations among Fe NO concentration,lung function and ACT score in children with asthma,ACT score can be used in assessing the disease control situation,lung function and Fe NO concentration can be used in assessing the airway inflammation and disease control situation.